DPP4 Inhibitor Attenuates Severe Acute Pancreatitis-Associated Intestinal Inflammation via Nrf2 Signaling

المؤلفون المشاركون

Zhou, Mengtao
Chen, Bi-Cheng
Shi, Ke-Qing
Zheng, Chenlei
Wang, Cheng
Ni, Xiao-feng
Zhou, Xiang
Wang, Weiming
Xu, Xiangxiang
Hu, Shanshan
Cai, Binbin
Sun, Linxiao
Chen, Gang

المصدر

Oxidative Medicine and Cellular Longevity

العدد

المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-11، 11ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2019-11-15

دولة النشر

مصر

عدد الصفحات

11

التخصصات الرئيسية

الأحياء

الملخص EN

Severe acute pancreatitis (SAP) is a challenging disease with high morbidity and mortality, often complicated by multiple organ dysfunction syndrome (MODS).

The intestine, a major organ involved in MODS, correlates strongly with the evolution of the disease.

In this study, we demonstrated that the DPP4 inhibitor, sitagliptin, protects SAP-associated intestinal injury both in vitro and in vivo.

These beneficial effects were achieved by suppressing oxidative stress and inflammatory responses.

Moreover, in sitagliptin-treated SAP mice, expression of Nrf2 was induced and that of NF-κB was reduced, compared to the control SAP mice.

In addition, we used Nrf2-/- mice to test the protective effect of Nrf2 during sitagliptin treatment of SAP; our results indicated that Nrf2-/- mice had greater pancreatic and intestinal injury than wild-type mice.

Taken together, high levels of ROS induced by SAP may be inhibited by sitagliptin, possibly by inactivating the Nrf2-NF-κB pathway.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Zhou, Xiang& Wang, Weiming& Wang, Cheng& Zheng, Chenlei& Xu, Xiangxiang& Ni, Xiao-feng…[et al.]. 2019. DPP4 Inhibitor Attenuates Severe Acute Pancreatitis-Associated Intestinal Inflammation via Nrf2 Signaling. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1204487

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Zhou, Xiang…[et al.]. DPP4 Inhibitor Attenuates Severe Acute Pancreatitis-Associated Intestinal Inflammation via Nrf2 Signaling. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1204487

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Zhou, Xiang& Wang, Weiming& Wang, Cheng& Zheng, Chenlei& Xu, Xiangxiang& Ni, Xiao-feng…[et al.]. DPP4 Inhibitor Attenuates Severe Acute Pancreatitis-Associated Intestinal Inflammation via Nrf2 Signaling. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1204487

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1204487