Nitrative Stress-Related Autophagic Insufficiency Participates in Hyperhomocysteinemia-Induced Renal Aging
المؤلفون المشاركون
Wang, Wen
Zhang, Shangyue
Zhang, Yuerong
Zhang, Xinyu
Luo, Chenghua
Cao, Yan
Ji, Dengyu
Yan, Wenjing
Xue, Ke
Chai, Jiayin
Dai, Hongyan
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-01-27
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
The kidneys are important organs that are susceptible to aging.
Hyperhomocysteinemia (HHcy) is a risk factor for nephropathy and is associated with chronic nephritis, purpuric nephritis, and nephrotic syndrome.
Numerous studies have shown that elevated serum homocysteine levels can damage the kidneys; however, the underlying mechanism of HHcy on kidney damage remains unclear.
In this study, we make use of a diet-induced HHcy rat model and in vitro cell culture to explore the role of autophagy in HHcy-induced renal aging and further explored the underlying mechanism.
We demonstrated that HHcy led to the development of renal aging.
Promoted kidney aging and autophagic insufficiency were involved in HHcy-induced renal aging.
HHcy decreased the expression of transcription factor EB (TFEB), the key transcription factor of autophagy-related genes in renal tissue.
Further experiments showed that nitrative stress levels were increased in the kidney of HHcy rats.
Interestingly, pretreatment with the peroxynitrite (ONOO-) scavenger FeTMPyP not only reduced the Hcy-induced nitrative stress in vitro but also partially attenuated the decrease in TFEB in both protein and mRNA levels.
Moreover, our results indicated that HHcy reduced TFEB expression and inhibited TFEB-mediated autophagy activation by elevating nitrative stress.
In conclusion, this study showed an important role of autophagic insufficiency in HHcy-induced renal aging, in which downregulation of TFEB plays a major role.
Furthermore, downexpression of TFEB was associated with increased nitrative stress in HHcy.
This study provides a novel insight into the mechanism and therapeutic strategy for renal aging.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Shangyue& Zhang, Yuerong& Zhang, Xinyu& Luo, Chenghua& Cao, Yan& Ji, Dengyu…[et al.]. 2020. Nitrative Stress-Related Autophagic Insufficiency Participates in Hyperhomocysteinemia-Induced Renal Aging. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1204492
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Shangyue…[et al.]. Nitrative Stress-Related Autophagic Insufficiency Participates in Hyperhomocysteinemia-Induced Renal Aging. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1204492
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Shangyue& Zhang, Yuerong& Zhang, Xinyu& Luo, Chenghua& Cao, Yan& Ji, Dengyu…[et al.]. Nitrative Stress-Related Autophagic Insufficiency Participates in Hyperhomocysteinemia-Induced Renal Aging. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1204492
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1204492
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر