Peptides from Animal Origin: A Systematic Review on Biological Sources and Effects on Skin Wounds
المؤلفون المشاركون
Sarandy, Mariáurea Matias
Gonçalves, Reggiani Vilela
Novaes, Rômulo Dias
Freitas, Mariella Bontempo
Altoé, Luciana Schulthais
Alves, Raul Santos
Alves, Levy Bueno
Silveira, Nelson José Freitas
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-10-23
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Background.
Skin wounds are closely correlated with opportunistic infections and sepsis risk.
Due to the need of more efficient healing drugs, animal peptides are emerging as new molecular platforms to accelerate skin wound closure and to prevent and control bacterial infection.
Aim.
The aim of this study was to evaluate the preclinical evidence on the impact of animal peptides on skin wound healing.
In addition, we carried out a critical analysis of the studies’ methodological quality.
Main Methods.
This systematic review was performed according to the PRISMA guidelines, using a structured search on the PubMed-Medline, Scopus, and Web of Science platforms to retrieve studies published until August 25, 2020 at 3 : 00 pm.
The studies included were limited to those that used animal models, investigated the effect of animal peptides with no association with other compounds on wound healing, and that were published in English.
Bias analysis and methodological quality assessments were examined through the SYRCLE’s RoB tool.
Results.
Thirty studies were identified using the PRISMA workflow.
In general, animal peptides were effective in accelerating skin wound healing, especially by increasing cellular proliferation, neoangiogenesis, colagenogenesis, and reepithelialization.
Considering standardized methodological quality indicators, we identified a marked heterogeneity in research protocols and a high risk of bias associated with limited characterization of the experimental designs.
Conclusion.
Animal peptides show a remarkable healing potential with biotechnological relevance for regenerative medicine.
However, rigorous experimental approaches are still required to clearly delimit the mechanisms underlying the healing effects and the risk-benefit ratio attributed to peptide-based treatments.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Alves, Raul Santos& Alves, Levy Bueno& Altoé, Luciana Schulthais& Sarandy, Mariáurea Matias& Freitas, Mariella Bontempo& Silveira, Nelson José Freitas…[et al.]. 2020. Peptides from Animal Origin: A Systematic Review on Biological Sources and Effects on Skin Wounds. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1204521
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Alves, Raul Santos…[et al.]. Peptides from Animal Origin: A Systematic Review on Biological Sources and Effects on Skin Wounds. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1204521
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Alves, Raul Santos& Alves, Levy Bueno& Altoé, Luciana Schulthais& Sarandy, Mariáurea Matias& Freitas, Mariella Bontempo& Silveira, Nelson José Freitas…[et al.]. Peptides from Animal Origin: A Systematic Review on Biological Sources and Effects on Skin Wounds. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1204521
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1204521
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر