Oxidative and Antioxidative Stress Linked Biomarkers in Ankylosing Spondylitis: A Systematic Review and Meta-analysis
المؤلفون المشاركون
Li, Jiaxiao
Liu, Suling
Cui, Yang
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-09-21
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Objective.
Ankylosing spondylitis (AS) is a chronic inflammatory disease that affects the axial skeleton, leading to joint disability.
Our study aims at investigating the change of oxidative and antioxidative stress linked biomarkers in AS.
Methods.
This systematic review and meta-analysis was performed following the Preferred Reporting Items of Systematic Reviews and Meta-Analyses (PRISMA) statement.
PubMed, Web of Science, and Cochrane Library databases till May 2020 were searched.
Only articles published in English were included.
Two reviewers screened relevant studies, extracted data, and assessed the quality of included studies using the Newcastle-Ottawa scale independently.
Either random or fixed effect model was adopted base on the heterogeneity testing by I2 statistic.
Standardized mean difference (SMD) and 95% confidence intervals (CI) of oxidative and antioxidative markers were calculated.
p value <0.05 was considered statistically significant.
Results.
A total of 22 studies including 931 AS patients and 917 healthy controls met the selection criteria.
Significantly increased levels of all oxidative stress markers except myeloperoxidase, and significantly decreased levels of total antioxidant status (SMD=−1.19, 95% CI -2.35 to -0.03, p=0.044) and paraoxonase 1(SMD=−1.01, 95% CI -1.78 to -0.24, p=0.010) in serum were observed in AS patients when compared with healthy controls.
However, there were no significant differences of all oxidative and anti-oxidative stress biomarkers in erythrocytes.
Additionally, the levels of malondialdehyde (SMD=0.51, 95% CI 0.21 to 0.81, p=0.001) and advanced oxidation protein products (SMD=0.95, 95% CI 0.58 to 1.31, p<0.001) in serum were significantly higher in active patients when compared with inactive AS patients.
Conclusion.
This meta-analysis demonstrated an overall increase of oxidative markers and decrease of antioxidative markers in AS, suggesting that oxidative stress may play an important role in the pathogenesis of AS.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Jiaxiao& Liu, Suling& Cui, Yang. 2020. Oxidative and Antioxidative Stress Linked Biomarkers in Ankylosing Spondylitis: A Systematic Review and Meta-analysis. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1204613
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Jiaxiao…[et al.]. Oxidative and Antioxidative Stress Linked Biomarkers in Ankylosing Spondylitis: A Systematic Review and Meta-analysis. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1204613
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Jiaxiao& Liu, Suling& Cui, Yang. Oxidative and Antioxidative Stress Linked Biomarkers in Ankylosing Spondylitis: A Systematic Review and Meta-analysis. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1204613
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1204613
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر