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Lactate Induces Cisplatin Resistance in S. cerevisiae through a Rad4p-Dependent Process
المؤلفون المشاركون
Amaral, Leslie
Mendes, Filipa
Côrte-Real, Manuela
Chaves, Susana Rodrigues
Sousa, Maria João
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-10-24
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Cisplatin is a widely used antineoplastic agent that has DNA as the main target, though cellular resistance hampers its therapeutic efficacy.
An emerging hallmark of cancer cells is their altered metabolism, characterized by increased glycolysis even under aerobic conditions, with increased lactate production (known as the Warburg effect).
Although this altered metabolism often results in increased resistance to chemotherapy, it also provides an opportunity for targeted therapeutic intervention.
It has been suggested that cisplatin cytotoxicity can be affected by tumor metabolism, though with varying effects.
We therefore sought to better characterize how lactate affects cisplatin sensitivity in the simplified Saccharomyces cerevisiae model.
We show that lactate renders yeast cells resistant to cisplatin, independently of growth rate or respiration ability.
We further show that histone acetylation is not affected, but histone phosphorylation is decreased in lactate-containing media.
Finally, we show that Rad4p, essential for nucleotide excision repair, is required for the observed phenotype and thus likely underlies the mechanism responsible for lactate-mediated resistance to cisplatin.
Overall, understanding how lactate modulates cisplatin sensitivity will aid in the development of new strategies to overcome drug resistance.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Amaral, Leslie& Mendes, Filipa& Côrte-Real, Manuela& Sousa, Maria João& Chaves, Susana Rodrigues. 2020. Lactate Induces Cisplatin Resistance in S. cerevisiae through a Rad4p-Dependent Process. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1204681
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Amaral, Leslie…[et al.]. Lactate Induces Cisplatin Resistance in S. cerevisiae through a Rad4p-Dependent Process. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1204681
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Amaral, Leslie& Mendes, Filipa& Côrte-Real, Manuela& Sousa, Maria João& Chaves, Susana Rodrigues. Lactate Induces Cisplatin Resistance in S. cerevisiae through a Rad4p-Dependent Process. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1204681
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1204681
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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