Single Point Mutation from E22-to-K in Aβ Initiates Early-Onset Alzheimer’s Disease by Binding with Catalase
المؤلفون المشاركون
Yue, Xiangpei
He, Rongqiao
Jiang, Wenjing
Zhao, Shengjie
YanYu, Wenjing
Yao, Dandan
Fei, Xuechao
Ai, Li
Di, Yalan
Zhang, Jingnan
Lyu, Jihui
Tong, Zhiqian
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-21، 21ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-12-24
دولة النشر
مصر
عدد الصفحات
21
التخصصات الرئيسية
الملخص EN
Amyloid-beta (Aβ) is a critical etiological factor for late-onset familial Alzheimer’s disease (AD).
However, an early-onset AD has been found to be related with an Aβ mutation in glutamic acid 22-to-lysine (Italian type E22K).
Why only one single point mutation at E22 residue induces AD remains unclear.
Here, we report that a Chinese familial AD pedigree with E22K mutation was associated with higher levels of serum hydrogen peroxide (H2O2) and lower activity of catalase (a H2O2 degrading enzyme) than controls.
Further, we found that E22K binding with catalase caused more severe H2O2 accumulation in the brains of E22K-injected rats than Aβ-injected rats.
Unexpectedly, H2O2 bound with the mutation site 22K residue of E22K and elicited more rapid aggregation of E22K than Aβ in vitro.
Moreover, H2O2 acted with E22K synergistically to induce higher cellular toxicity than with Aβ.
Notably, intrahippocampal infusion of E22K led to more severe plaque deposition, neuron death, and more rapid memory decline than Aβ-injected rats.
However, L-cysteine, a H2O2 scavenger, not only prevented self-aggregation of E22K but also reduced H2O2-promoted E22K assembly in vitro; subsequently, it alleviated Alzheimer-related phenotypes.
Hence, E22K binding with catalase promotes the early onset of familial AD, and L-cys may reverse this disease.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jiang, Wenjing& YanYu, Wenjing& Yao, Dandan& Fei, Xuechao& Ai, Li& Di, Yalan…[et al.]. 2020. Single Point Mutation from E22-to-K in Aβ Initiates Early-Onset Alzheimer’s Disease by Binding with Catalase. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-21.
https://search.emarefa.net/detail/BIM-1204685
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jiang, Wenjing…[et al.]. Single Point Mutation from E22-to-K in Aβ Initiates Early-Onset Alzheimer’s Disease by Binding with Catalase. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-21.
https://search.emarefa.net/detail/BIM-1204685
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jiang, Wenjing& YanYu, Wenjing& Yao, Dandan& Fei, Xuechao& Ai, Li& Di, Yalan…[et al.]. Single Point Mutation from E22-to-K in Aβ Initiates Early-Onset Alzheimer’s Disease by Binding with Catalase. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-21.
https://search.emarefa.net/detail/BIM-1204685
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1204685
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر