Impact of Coenzyme Q10 Administration on Lead Acetate-Induced Testicular Damage in Rats
المؤلفون المشاركون
El-Khadragy, Manal F.
Kassab, Rami B.
AL-Megrin, Wafa A.
AlSadhan, Norah A.
Metwally, Dina M.
El-Hennamy, Rehab E.
Salem, Fatma Elzahraa H.
Abdel Moneim, Ahmed E.
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-06-03
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Exposure to lead (Pb) causes multiorgan dysfunction including reproductive impairments.
Here, we examined the protective effects of coenzyme Q10 (CoQ10) administration on testicular injury induced by lead acetate (PbAc) exposure in rats.
This study employed four experimental groups (n=7) that underwent seven days of treatment as follows: control group intraperitoneally (i.p.) treated with 0.1 ml of 0.9% NaCl containing 1% Tween 80 (v:v), CoQ10 group that was i.p.
injected with 10 mg/kg CoQ10, PbAc group that was i.p.
treated with PbAc (20 mg/kg), and PbAc+CoQ10 group that was i.p.
injected with CoQ10 2 h after PbAc.
PbAc injection resulted in increasing residual Pb levels in the testis and reducing testosterone, luteinizing hormone, and follicle-stimulating hormone levels.
Additionally, PbAc exposure resulted in significant oxidative damage to the tissues on the testes.
PbAc raised the levels of prooxidants (malondialdehyde and nitric oxide) and reduced the amount of endogenous antioxidative proteins (glutathione and its derivative enzymes, catalase, and superoxide dismutase) available in the cell.
Moreover, PbAc induced the inflammatory response as evidenced by the upregulation of inflammatory mediators (tumor necrosis factor-alpha and interleukin-1 beta).
Further, PbAc treatment induced apoptosis in the testicular cells, as indicated by an increase in Bax and caspase 3 expression, and reduced Bcl2 expression.
CoQ10 supplementation improved testicular function by inhibiting Pb accumulation, oxidative stress, inflammation, cell death, and histopathological changes following PbAc exposure.
Our findings suggest that CoQ10 can act as a natural therapeutic agent to protect against the reproductive impairments associated with PbAc exposure.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
El-Khadragy, Manal F.& AL-Megrin, Wafa A.& AlSadhan, Norah A.& Metwally, Dina M.& El-Hennamy, Rehab E.& Salem, Fatma Elzahraa H.…[et al.]. 2020. Impact of Coenzyme Q10 Administration on Lead Acetate-Induced Testicular Damage in Rats. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1204689
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
El-Khadragy, Manal F.…[et al.]. Impact of Coenzyme Q10 Administration on Lead Acetate-Induced Testicular Damage in Rats. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1204689
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
El-Khadragy, Manal F.& AL-Megrin, Wafa A.& AlSadhan, Norah A.& Metwally, Dina M.& El-Hennamy, Rehab E.& Salem, Fatma Elzahraa H.…[et al.]. Impact of Coenzyme Q10 Administration on Lead Acetate-Induced Testicular Damage in Rats. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1204689
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1204689
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر