Sex Differences in Age-Associated Type 2 Diabetes in Rats—Role of Estrogens and Oxidative Stress
المؤلفون المشاركون
Abdelaziz, Kheira M.
Lopez-Grueso, R.
Mas-Bargues, C.
Díaz, Ana
Viña, Jose
Gambini, Juan
Monleón, Daniel
Borrás, Consuelo
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-04-07
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Females live longer than males, and the estrogens are one of the reasons for this difference.
We reported some years ago that estrogens are able to protect rats against oxidative stress, by inducing antioxidant genes.
Type 2 diabetes is an age-associated disease in which oxidative stress is involved, and moreover, some studies show that the prevalence is higher in men than in women, and therefore there are sex-associated differences.
Thus, the aim of this study was to evaluate the role of estrogens in protecting against oxidative stress in type 2 diabetic males and females.
For this purpose, we used Goto-Kakizaki rats, which develop type 2 diabetes with age.
We found that female diabetic rats showed lower glycaemia levels with age than did diabetic males and that estrogens enhanced insulin sensitivity in diabetic females.
Moreover, glucose uptake, measured by positron emission tomography, was higher in the female brain, cerebellum, and heart than in those from male diabetic rats.
There were also sex-associated differences in the plasma metabolic profile as determined by metabolomics.
The metabolic profile was similar between estrogen-replaced and control diabetic rats and different from ovariectomized diabetic rats.
Oxidative stress is involved in these differences.
We showed that hepatic mitochondria from females produced less hydrogen peroxide levels and exhibited lower xanthine oxidase activity.
We also found that hepatic mitochondrial glutathione oxidation and lipid oxidation levels were lower in diabetic females when compared with diabetic males.
Ovariectomy induced oxidative stress, and estrogen replacement therapy prevented it.
These findings provide evidence for estrogen beneficial effects in type 2 diabetes and should be considered when prescribing estrogen replacement therapy to menopausal women.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Díaz, Ana& Lopez-Grueso, R.& Gambini, Juan& Monleón, Daniel& Mas-Bargues, C.& Abdelaziz, Kheira M.…[et al.]. 2019. Sex Differences in Age-Associated Type 2 Diabetes in Rats—Role of Estrogens and Oxidative Stress. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1204771
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Díaz, Ana…[et al.]. Sex Differences in Age-Associated Type 2 Diabetes in Rats—Role of Estrogens and Oxidative Stress. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-13.
https://search.emarefa.net/detail/BIM-1204771
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Díaz, Ana& Lopez-Grueso, R.& Gambini, Juan& Monleón, Daniel& Mas-Bargues, C.& Abdelaziz, Kheira M.…[et al.]. Sex Differences in Age-Associated Type 2 Diabetes in Rats—Role of Estrogens and Oxidative Stress. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1204771
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1204771
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر