Inhibition of JNK Alleviates Chronic Hypoperfusion-Related Ischemia Induces Oxidative Stress and Brain Degeneration via Nrf2HO-1 and NF-κB Signaling
المؤلفون المشاركون
Khan, Muhammad Sohail
Khan, Amjad
Ahmad, Sareer
Ahmad, Riaz
Rehman, Inayat U. R.
Ikram, Muhammad
Kim, Myeong Ok
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-18، 18ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-06-16
دولة النشر
مصر
عدد الصفحات
18
التخصصات الرئيسية
الملخص EN
Cerebral ischemia is one of the leading causes of neurological disorders.
The exact molecular mechanism related to chronic unilateral cerebral ischemia-induced neurodegeneration and memory deficit has not been precisely elucidated.
In this study, we examined the effect of chronic ischemia on the induction of oxidative stress and c-Jun N-terminal kinase-associated detrimental effects and unveiled the inhibitory effect of specific JNK inhibitor (SP600125) on JNK-mediated brain degeneration in adult mice.
Our behavioral, biochemical, and immunofluorescence studies revealed that chronic ischemic injuries sustained increased levels of oxidative stress-induced active JNK for a long time, whereas SP600125 significantly reduced the elevated level of active JNK and further regulated Nrf2/HO-1 and NF-κB signaling, which have been confirmed in vivo.
Neuroinflammatory mediators and loss of neuronal cells was significantly reduced with the administration of SP600125.
Ischemic brain injury caused synaptic dysfunction and memory impairment in mice.
However, these were significantly improved with SP600125.
On the whole, these findings suggest that elevated ROS-mediated JNK is a key mediator in chronic ischemic conditions and has a crucial role in neuroinflammation, neurodegeneration, and memory dysfunction.
Our findings suggest that chronic oxidative stress associated JNK would be a potential target in time-dependent studies of chronic ischemic conditions induced brain degeneration.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Khan, Muhammad Sohail& Khan, Amjad& Ahmad, Sareer& Ahmad, Riaz& Rehman, Inayat U. R.& Ikram, Muhammad…[et al.]. 2020. Inhibition of JNK Alleviates Chronic Hypoperfusion-Related Ischemia Induces Oxidative Stress and Brain Degeneration via Nrf2HO-1 and NF-κB Signaling. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-18.
https://search.emarefa.net/detail/BIM-1204790
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Khan, Muhammad Sohail…[et al.]. Inhibition of JNK Alleviates Chronic Hypoperfusion-Related Ischemia Induces Oxidative Stress and Brain Degeneration via Nrf2HO-1 and NF-κB Signaling. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-18.
https://search.emarefa.net/detail/BIM-1204790
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Khan, Muhammad Sohail& Khan, Amjad& Ahmad, Sareer& Ahmad, Riaz& Rehman, Inayat U. R.& Ikram, Muhammad…[et al.]. Inhibition of JNK Alleviates Chronic Hypoperfusion-Related Ischemia Induces Oxidative Stress and Brain Degeneration via Nrf2HO-1 and NF-κB Signaling. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-18.
https://search.emarefa.net/detail/BIM-1204790
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1204790
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر