Itaconate: A Metabolite Regulates Inflammation Response and Oxidative Stress

المؤلفون المشاركون

Li, Ruidong
Wang, Yaxin
Tao, Kaixiong
Zhang, Peng

المصدر

Oxidative Medicine and Cellular Longevity

العدد

المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-11، 11ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2020-07-17

دولة النشر

مصر

عدد الصفحات

11

التخصصات الرئيسية

الأحياء

الملخص EN

Metabolic products can lead to crucial biological function alterations.

Itaconate is probably the best example of how a metabolic process can be diverted to generate an immunomodulator effect in macrophages.

Through inflammatory stimuli, such as lipopolysaccharide, the immune response gene 1 is activated and promotes the production of itaconate from the tricarboxylic acid cycle by decarboxylating cis-aconitate.

Itaconate has been reported to have multiple immunoregulatory and antioxidative effects.

In addition, reports have described its antibacterial and protumor effects.

The involved mechanism in these effects includes the activation of nuclear factor E2-related factor 2 by alkylation of Kelch-like ECH-associated protein 1, inhibition of aerobic glycolysis by targeting glyceraldehyde-3-phosphate dehydrogenase and fructose-bisphosphate aldolase A, inhibition of succinate dehydrogenase, and blockade of IκBζ translation.

All of these discoveries elucidated the transformation of the pro- into anti-inflammatory status in macrophages, which is crucial in innate immunity and set the ground for the emerging therapeutic implications of itaconate.

In this review, we point out that itaconate is a novel and pivotal metabolic determinant of the immunoregulatory response in macrophages and highlight studies that have improved our understanding of the connection between the immune response and metabolism.

In addition, we shed light on the therapeutic potential of itaconate and its derivatives to treat inflammatory diseases.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Li, Ruidong& Zhang, Peng& Wang, Yaxin& Tao, Kaixiong. 2020. Itaconate: A Metabolite Regulates Inflammation Response and Oxidative Stress. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1204842

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Li, Ruidong…[et al.]. Itaconate: A Metabolite Regulates Inflammation Response and Oxidative Stress. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1204842

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Li, Ruidong& Zhang, Peng& Wang, Yaxin& Tao, Kaixiong. Itaconate: A Metabolite Regulates Inflammation Response and Oxidative Stress. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1204842

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1204842