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Vitamin D Deficiency Is Associated with Muscle Atrophy and Reduced Mitochondrial Function in Patients with Chronic Low Back Pain
المؤلفون المشاركون
Antosiewicz, J.
Flis, Damian Jozef
Kaczor, Jan Jacek
Dzik, Katarzyna Patrycja
Skrobot, Wojciech
Kaczor, Katarzyna Barbara
Karnia, Mateusz Jakub
Libionka, Witold
Kloc, Wojciech
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-06-02
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Recent studies show that vitamin D deficiency may be responsible for muscle atrophy.
The purpose of this study was to investigate markers of muscle atrophy, signalling proteins, and mitochondrial capacity in patients with chronic low back pain with a focus on gender and serum vitamin D level.
The study involved patients with chronic low back pain (LBP) qualified for posterior lumbar interbody fusion (PLIF).
Patients were divided into three groups: supplemented (SUPL) with vitamin D (3200 IU/day for 5 weeks), placebo with normal levels of vitamin D (SUF), and the placebo group with vitamin D deficiency (DEF).
The marker of muscle atrophy including atrogin-1 and protein content for IGF-1, Akt, FOXO3a, PGC-1α, and citrate synthase (CS) activity were determined in collected multifidus muscle.
In the paraspinal muscle, IGF-1 levels were higher in the SUF group as compared to both the SUPL and DEF groups (p<0.05).
In the SUPL group, we found significantly increased protein content for pAkt (p<0.05) and decreased level of FOXO3a (p<0.05).
Atrogin-1 content was significantly different between men and women (p<0.05).
The protein content of PGC-1α was significantly higher in the SUF group as compared to the DEF group (p<0.05).
CS activity in the paraspinal muscle was higher in the SUPL group than in the DEF group (p<0.05).
Our results suggest that vitamin D deficiency is associated with elevated oxidative stress, muscle atrophy, and reduced mitochondrial function in the multifidus muscle.
Therefore, vitamin D-deficient LBP patients might have reduced possibilities on early and effective rehabilitation after PLIF surgery.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Dzik, Katarzyna Patrycja& Skrobot, Wojciech& Kaczor, Katarzyna Barbara& Flis, Damian Jozef& Karnia, Mateusz Jakub& Libionka, Witold…[et al.]. 2019. Vitamin D Deficiency Is Associated with Muscle Atrophy and Reduced Mitochondrial Function in Patients with Chronic Low Back Pain. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1204881
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Dzik, Katarzyna Patrycja…[et al.]. Vitamin D Deficiency Is Associated with Muscle Atrophy and Reduced Mitochondrial Function in Patients with Chronic Low Back Pain. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1204881
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Dzik, Katarzyna Patrycja& Skrobot, Wojciech& Kaczor, Katarzyna Barbara& Flis, Damian Jozef& Karnia, Mateusz Jakub& Libionka, Witold…[et al.]. Vitamin D Deficiency Is Associated with Muscle Atrophy and Reduced Mitochondrial Function in Patients with Chronic Low Back Pain. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1204881
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1204881
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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