Vitamin D Deficiency Aggravates Hepatic Oxidative Stress and Inflammation during Chronic Alcohol-Induced Liver Injury in Mice
المؤلفون المشاركون
Xu, De-Xiang
Hu, Chun-Qiu
Bo, Qing-Li
Chu, Lan-Lan
Hu, Yong-Di
Fu, Lin
Wang, Guo-Xiu
Lu, Yan
Liu, Xiao-Jing
Wang, Hua
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-02-27
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Vitamin D deficiency has been reported in alcoholics.
This study is aimed at evaluating the effects of vitamin D deficiency on chronic alcohol-induced liver injury in mice.
Mice were fed with modified Lieber-DeCarli liquid diets for 6 weeks to establish an animal model of chronic alcohol-induced liver injury.
In the VDD+EtOH group, mice were fed with modified diets, in which vitamin D was depleted.
Vitamin D deficiency aggravated alcohol-induced liver injury.
Furthermore, vitamin D deficiency aggravated hepatocyte apoptosis during alcohol-induced liver injury.
Although it has a little effect on hepatic TG content, vitamin D deficiency promoted alcohol-induced hepatic GSH depletion and lipid peroxidation.
Further analysis showed that vitamin D deficiency further increased alcohol-induced upregulation of hepatic inducible nitric oxide synthase (inos), two NADPH oxidase subunits p47phox and gp91phox, and heme oxygenase- (HO-) 1.
By contrast, vitamin D deficiency attenuated alcohol-induced upregulation of hepatic antioxidant enzyme genes, such as superoxide dismutase (sod) 1 and gshpx.
In addition, vitamin D deficiency significantly elevated alcohol-induced upregulation of hepatic proinflammatory cytokines and chemokines.
Taken together, these results suggest that vitamin D deficiency aggravates hepatic oxidative stress and inflammation during chronic alcohol-induced liver injury.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hu, Chun-Qiu& Bo, Qing-Li& Chu, Lan-Lan& Hu, Yong-Di& Fu, Lin& Wang, Guo-Xiu…[et al.]. 2020. Vitamin D Deficiency Aggravates Hepatic Oxidative Stress and Inflammation during Chronic Alcohol-Induced Liver Injury in Mice. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1204924
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hu, Chun-Qiu…[et al.]. Vitamin D Deficiency Aggravates Hepatic Oxidative Stress and Inflammation during Chronic Alcohol-Induced Liver Injury in Mice. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-14.
https://search.emarefa.net/detail/BIM-1204924
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hu, Chun-Qiu& Bo, Qing-Li& Chu, Lan-Lan& Hu, Yong-Di& Fu, Lin& Wang, Guo-Xiu…[et al.]. Vitamin D Deficiency Aggravates Hepatic Oxidative Stress and Inflammation during Chronic Alcohol-Induced Liver Injury in Mice. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1204924
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1204924
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر