The Latest View on the Mechanism of Ferroptosis and Its Research Progress in Spinal Cord Injury
المؤلفون المشاركون
Liu, Suixin
Chen, Yixin
Li, Jianjun
Li, Zhe
Quan, Jing
Liu, Xinzhou
Tang, Yinbo
Liu, Bin
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-08-28
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Ferroptosis is a recently identified nonapoptotic form of cell death whose major markers are iron dependence and accumulation of lipid reactive oxygen species, accompanied by morphological changes such as shrunken mitochondria and increased membrane density.
It appears to contribute to the death of tumors, ischemia-reperfusion, acute renal failure, and nervous system diseases, among others.
The generative mechanism of ferroptosis includes iron overloading, lipid peroxidation, and downstream execution, while the regulatory mechanism involves the glutathione/glutathione peroxidase 4 pathway, as well as the mevalonate pathway and the transsulfuration pathway.
In-depth research has continuously developed and enriched knowledge on the mechanism by which ferroptosis occurs.
In recent years, reports of the noninterchangeable role played by selenium in glutathione peroxidase 4 and its function in suppressing ferroptosis and the discovery of ferroptosis suppressor protein 1, identified as a ferroptosis resistance factor parallel to the glutathione peroxidase 4 pathway, have expanded and deepened our understanding of the mechanism by which ferroptosis works.
Ferroptosis has been reported in spinal cord injury animal model experiments, and the inhibition of ferroptosis could promote the recovery of neurological function.
Here, we review the latest studies on mechanism by which ferroptosis occurs, focusing on the ferroptosis execution and the contents related to selenium and ferroptosis suppressor protein 1.
In addition, we summarize the current research status of ferroptosis in spinal cord injury.
The aim of this review is to better understand the mechanisms by which ferroptosis occurs and its role in the pathophysiological process of spinal cord injury, so as to provide a new idea and frame of reference for further exploration.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chen, Yixin& Liu, Suixin& Li, Jianjun& Li, Zhe& Quan, Jing& Liu, Xinzhou…[et al.]. 2020. The Latest View on the Mechanism of Ferroptosis and Its Research Progress in Spinal Cord Injury. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1205105
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chen, Yixin…[et al.]. The Latest View on the Mechanism of Ferroptosis and Its Research Progress in Spinal Cord Injury. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1205105
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chen, Yixin& Liu, Suixin& Li, Jianjun& Li, Zhe& Quan, Jing& Liu, Xinzhou…[et al.]. The Latest View on the Mechanism of Ferroptosis and Its Research Progress in Spinal Cord Injury. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1205105
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1205105
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر