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Ameliorating Effect of Klotho Protein on Rat Heart during IR Injury
المؤلفون المشاركون
Krzywonos-Zawadzka, Anna
Olejnik, Agnieszka
Banaszkiewicz, Marta
Bil-Lula, Iwona
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-10-17
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
An essential procedure for the treatment of myocardial infarction is restoration of blood flow in the obstructed infarct artery, which may cause ischaemia/reperfusion (I/R) injury.
Heart I/R injury manifests in oxidative stress, metabolic and morphological disorders, or cardiac contractile dysfunction.
Klotho protein was found to be produced in the heart tissue and participate in antioxidation or ion homeostasis.
The aim of this study was to examine an influence of Klotho protein on the heart subjected to I/R injury.
Wistar rats served as a surrogate heart model ex vivo.
Rat hearts perfused using the Langendorff method were subjected to global no-flow ischaemia, and isolated rat cardiomyocytes underwent chemical I/R in vitro, with or without recombinant Klotho protein administration.
Haemodynamic parameters of heart function, cell contractility, markers of I/R injury and oxidative stress, and the level of contractile proteins such as myosin light chain 1 (MLC1) and troponin I (TnI) were measured.
The treatment of hearts subjected to I/R injury with Klotho protein resulted in a recovery of heart mechanical function and ameliorated myocyte contractility.
This improvement was associated with decreased tissue injury, enhanced antioxidant capacity, and reduced release of MLC1 and TnI.
The present research showed the contribution of Klotho to cardioprevention during I/R.
Thus, Klotho protein may support the protection from I/R injury and prevention of contractile dysfunction in the rat heart.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Olejnik, Agnieszka& Krzywonos-Zawadzka, Anna& Banaszkiewicz, Marta& Bil-Lula, Iwona. 2020. Ameliorating Effect of Klotho Protein on Rat Heart during IR Injury. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1205127
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Olejnik, Agnieszka…[et al.]. Ameliorating Effect of Klotho Protein on Rat Heart during IR Injury. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1205127
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Olejnik, Agnieszka& Krzywonos-Zawadzka, Anna& Banaszkiewicz, Marta& Bil-Lula, Iwona. Ameliorating Effect of Klotho Protein on Rat Heart during IR Injury. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1205127
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1205127
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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