Obeticholic Acid Protects against Gestational Cholestasis-Induced Fetal Intrauterine Growth Restriction in Mice
المؤلفون المشاركون
Chen, Yuan-Hua
Xu, De-Xiang
Wang, Hua
Chen, Wei
Gao, Xing-Xing
Ma, Li
Liu, Zhi-Bing
Li, Li
Gao, Lan
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-17، 17ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-11-15
دولة النشر
مصر
عدد الصفحات
17
التخصصات الرئيسية
الملخص EN
Gestational cholestasis is a common disease and is associated with adverse pregnancy outcomes.
However, there are still no effective treatments.
We investigated the effects of obeticholic acid (OCA) on fetal intrauterine growth restriction (IUGR) during 17α-ethynylestradiol- (E2-) induced gestational cholestasis in mice.
All pregnant mice except controls were subcutaneously injected with E2 (0.625 mg/kg) daily from gestational day (GD) 13 to GD17.
Some pregnant mice were orally administered with OCA (5 mg/kg) daily from GD12 to GD17.
As expected, OCA activated placental, maternal, and fetal hepatic FXR signaling.
Additionally, exposure with E2 during late pregnancy induced cholestasis, whereas OCA alleviated E2-induced cholestasis.
Gestational cholestasis caused reduction of fetal weight and crown-rump length and elevated the incidence of IUGR.
OCA decreased the incidence of IUGR during cholestasis.
Interestingly, OCA attenuated reduction of blood sinusoid area in placental labyrinth layer and inhibited downregulation of placental sodium-coupled neutral amino acid transporter- (SNAT-) 2 during cholestasis.
Additional experiment found that OCA attenuated glutathione depletion and lipid peroxidation in placenta and fetal liver and placental protein nitration during cholestasis.
Moreover, OCA inhibited the upregulation of placental NADPH oxidase-4 and antioxidant genes during cholestasis.
OCA activated antioxidant Nrf2 signaling during cholestasis.
Overall, we demonstrated that OCA treatment protected against gestational cholestasis-induced placental dysfunction and IUGR through suppressing placental oxidative stress and maintaining bile acid homeostasis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chen, Wei& Gao, Xing-Xing& Ma, Li& Liu, Zhi-Bing& Li, Li& Wang, Hua…[et al.]. 2019. Obeticholic Acid Protects against Gestational Cholestasis-Induced Fetal Intrauterine Growth Restriction in Mice. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-17.
https://search.emarefa.net/detail/BIM-1205148
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chen, Wei…[et al.]. Obeticholic Acid Protects against Gestational Cholestasis-Induced Fetal Intrauterine Growth Restriction in Mice. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-17.
https://search.emarefa.net/detail/BIM-1205148
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chen, Wei& Gao, Xing-Xing& Ma, Li& Liu, Zhi-Bing& Li, Li& Wang, Hua…[et al.]. Obeticholic Acid Protects against Gestational Cholestasis-Induced Fetal Intrauterine Growth Restriction in Mice. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-17.
https://search.emarefa.net/detail/BIM-1205148
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1205148
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر