Potential Role of Nutrient Intake and Malnutrition as Predictors of Uremic Oxidative Toxicity in Patients with End-Stage Renal Disease
المؤلفون المشاركون
de Miranda, Aline Silva
Novaes, Rômulo Dias
Gonçalves, Reggiani Vilela
Silva, Robson E.
Justino, Patrícia B. I.
Brigagão, Maísa R. P. L.
Moraes, Gabriel O. I.
Simões e Silva, Ana Cristina
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-11-29
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Oxidative stress is an important risk factor for cardiovascular disease and death in hemodialysis (HD) patients.
However, whether biochemical and nutritional markers might be useful to stratify HD patients according to the risk of oxidative damage remains unclear.
We investigated whether low-cost and easily available parameters such as the profile of nutrients intake, nutritional status, and antioxidant defenses can predict lipid and protein oxidation in HD patients.
Forty-nine HD patients (women=20, men=29), ranging from 18 to 65 years of age (73.5%) were submitted to biochemical and nutritional analysis.
At least 93.9% of HD patients had malnutrition.
A patient’s stratification according to nutritional risk was highly coherent with anthropometric parameters and nutrients intake, which were complementarily used as markers of malnutrition.
Nutritional stratification was unable to reveal differences in the oxidative status.
On the other hand, carbohydrate and zinc intake, serum zinc (Zn), glutathione peroxidase (GPx) activity, total antioxidant capacity (TAC), and nonprotein antioxidants (npAC) in serum were predictive markers of lipid (R2=0.588, P<0.001) and protein (R2=0.581, P<0.001) oxidation.
Interestingly, GPx activity, TAC, and npAC exhibited good (>80%<90%) or excellent (>90%) accuracy to estimate lipid oxidation (P≤0.01).
Regarding the prediction of protein oxidation, GPx activity and TAC presented regular accuracy (>70%<80%), and Zn serum levels exhibited good sensitivity (P≤0.01).
Herein, we provided evidence that clinical characteristics relevant to predict different levels of lipid and protein oxidation in HD patients can be easily obtained, during routine hospital visits by means of the combined analyses of biochemical and nutritional parameters.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Silva, Robson E.& Simões e Silva, Ana Cristina& de Miranda, Aline Silva& Justino, Patrícia B. I.& Brigagão, Maísa R. P. L.& Moraes, Gabriel O. I.…[et al.]. 2019. Potential Role of Nutrient Intake and Malnutrition as Predictors of Uremic Oxidative Toxicity in Patients with End-Stage Renal Disease. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1205157
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Silva, Robson E.…[et al.]. Potential Role of Nutrient Intake and Malnutrition as Predictors of Uremic Oxidative Toxicity in Patients with End-Stage Renal Disease. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1205157
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Silva, Robson E.& Simões e Silva, Ana Cristina& de Miranda, Aline Silva& Justino, Patrícia B. I.& Brigagão, Maísa R. P. L.& Moraes, Gabriel O. I.…[et al.]. Potential Role of Nutrient Intake and Malnutrition as Predictors of Uremic Oxidative Toxicity in Patients with End-Stage Renal Disease. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1205157
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1205157
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر