Danshen Attenuates Intervertebral Disc Degeneration via Antioxidation in SD Rats
المؤلفون المشاركون
Liu, Hongpeng
Zhou, Bing
Qin, Rongqing
Dai, Shouqian
Zhang, Xing
Zhou, Pin
Hu, Chuanliang
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-12-23
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Objective.
To investigate the effects of Danshen on the imaging and histological parameters, expression levels of ECM-associated proteins and inflammatory factors, and antioxidative activity in the degenerated intervertebral disc (IVD) of SD rats.
Methods.
Sixty male rats were randomly divided into three groups (control, IDD, and Danshen IDD).
Percutaneous needle puncture in Co8-9 intervertebral disc was conducted in all rats of the IDD and Danshen IDD groups to induce intervertebral disc degeneration (IDD).
After operation, animals of the Danshen IDD group were administrated with Danshen granules (3 g/kg body weight ) by gavage once a day.
Four weeks later, the coccygeal vertebrae were harvested and used for imaging (disc height and MR signal), histological, immunohistochemical, and biochemical [water content, glycosaminoglycans (GAG), superoxide dismutase (SOD2), glutathione (GSH), and malondialdehyde (MDA)] analyses.
Results.
The puncture induced significant decreased IVD space and MR T2 signal at both 2 and 4 weeks, which were attenuated by Danshen treatment.
The disc degeneration in the IDD group (HE and Safranin O-Fast Green histological staining was markedly more serious compared with that in the control group.
Four weeks of Danshen treatment significantly alleviated this degeneration compared with the IDD group.
Needle puncture resulted in the upregulation of IL-1β and TNF-α, MMP-3, and downregulation of COL2 and aggrecan in the IDD group.
However, this change was significantly weakened by Danshen treatment.
Significantly lower water and GAG content, as well as the SOD2 and GSH levels, in the IDD group were found compared with those in the control group.
However, the above parameters of the Danshen IDD group were significantly higher than those of the IDD group.
Danshen treatment significantly decreased the content of MDA which was increased by needle puncture in the IDD group.
Conclusion.
Danshen can attenuate intervertebral disc degeneration in SD rats by suppressing the oxidation reaction.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Qin, Rongqing& Dai, Shouqian& Zhang, Xing& Liu, Hongpeng& Zhou, Bing& Zhou, Pin…[et al.]. 2020. Danshen Attenuates Intervertebral Disc Degeneration via Antioxidation in SD Rats. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1205185
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Qin, Rongqing…[et al.]. Danshen Attenuates Intervertebral Disc Degeneration via Antioxidation in SD Rats. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1205185
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Qin, Rongqing& Dai, Shouqian& Zhang, Xing& Liu, Hongpeng& Zhou, Bing& Zhou, Pin…[et al.]. Danshen Attenuates Intervertebral Disc Degeneration via Antioxidation in SD Rats. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1205185
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1205185
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر