Chitosan Oligosaccharides Show Protective Effects in Coronary Heart Disease by Improving Antioxidant Capacity via the Increase in Intestinal Probiotics
المؤلفون المشاركون
Zhang, Lirong
Jiang, Tiechao
Xing, Xiaohong
Liu, Zhen
Zhao, Jixue
Liu, Xin
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-03-10
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
We explored the effects of chitosan oligosaccharides (COS) on coronary heart disease (CHD) patients.
The component of COS was measured by matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS).
CHD patients were evenly assigned into the COS group (COG) and the placebo group (CG).
The duration of treatment was 6 months and therapeutic results were explored by measuring left ventricular ejection fraction (LVEF) value, Lee scores, quality of life (QOL), blood urea nitrogen, and serum creatinine.
The intestinal flora were determined by 16s rDNA sequencing.
The circulating antioxidant levels and lipid profiles were compared between two groups.
There were 7 different degrees of polymerization (DP4-10) in COS.
Lee scores, QOL scores, and LVEF values in the COG group were higher than those in the CG group (P<0.05).
COS treatment improved blood urea nitrogen and serum creatinine when compared with controls (P<0.05).
Circulating antioxidant levels were higher in the COG group than in the CG group.
COS consumption increased the serum levels of SOD and GSH and reduced the levels of ALT and AST (P<0.05).
Meanwhile, lipid profiles were improved in the COG group.
COS consumption increased the abundance of Faecalibacterium, Alistipes, and Escherichia and decreased the abundance of Bacteroides, Megasphaera, Roseburia, Prevotella, and Bifidobacterium (P<0.05).
On the other hand, COS consumption increased the probiotic species Lactobacillus, Lactococcus, and Phascolarctobacterium.
The increased species have been reported to be associated with antioxidant properties or lipid improvement.
COS had similar effects with chitohexaose on the growth rate of these species.
Therefore, COS ameliorate the symptoms of CHD patients by improving antioxidant capacities and lipid profiles via the increase of probiotics in the intestinal flora.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jiang, Tiechao& Xing, Xiaohong& Zhang, Lirong& Liu, Zhen& Zhao, Jixue& Liu, Xin. 2019. Chitosan Oligosaccharides Show Protective Effects in Coronary Heart Disease by Improving Antioxidant Capacity via the Increase in Intestinal Probiotics. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1205243
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jiang, Tiechao…[et al.]. Chitosan Oligosaccharides Show Protective Effects in Coronary Heart Disease by Improving Antioxidant Capacity via the Increase in Intestinal Probiotics. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1205243
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jiang, Tiechao& Xing, Xiaohong& Zhang, Lirong& Liu, Zhen& Zhao, Jixue& Liu, Xin. Chitosan Oligosaccharides Show Protective Effects in Coronary Heart Disease by Improving Antioxidant Capacity via the Increase in Intestinal Probiotics. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1205243
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1205243
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر