Sex Differences in Progression of Diabetic Cardiomyopathy in OVE26 Type 1 Diabetic Mice
المؤلفون المشاركون
Zhou, Shanshan
Zheng, Yang
Zhang, Jian
Tang, Xiaoqiang
Jiang, Saizhi
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-05-14
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
OVE26 mice are a widely used transgenic model of early-onset type 1 diabetes.
These mice overexpress calmodulin in their pancreatic β cells, develop severe diabetes within the first weeks of life, and progress to severe diabetic complications including diabetic nephropathy and diabetic cardiomyopathy (DCM).
To date, diabetic nephropathy in OVE26 mice has been well explored, leaving the progression of DCM and the gender impact in this type 1 diabetes model still unrevealed.
In our study, male and female OVE26 mice and age-matched nondiabetic FVB mice were examined at 4, 12, 24, and 36 weeks for their cardiac function, body weight, blood glucose, and heart weight/tibia length ratio.
Further, histopathological examination and Western blot analysis for the key markers demonstrate that DCM appears at 24 weeks OVE26 mice, initiating with cardiac senescence, followed by fibrosis and then cardiac dysfunction.
Mitochondrial respiration function analysis showed no indication of dysfunction in OVE26 mice at 24 weeks of age in both genders.
In addition, no significant difference for the pathogenic progression was observed between OVE26 and FVB mice in both males and females.
In conclusion, this study suggests cardiac senescence and fibrosis, which may be amended by sex differences, play key roles in the progression of DCM in OVE26 mice.
The comprehensive characterization of diabetic cardiomyopathy progression and the sex difference impact in OVE26 mice provides a basis for future study on DCM using OVE26 mice.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tang, Xiaoqiang& Jiang, Saizhi& Zhang, Jian& Zhou, Shanshan& Zheng, Yang. 2020. Sex Differences in Progression of Diabetic Cardiomyopathy in OVE26 Type 1 Diabetic Mice. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1205246
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tang, Xiaoqiang…[et al.]. Sex Differences in Progression of Diabetic Cardiomyopathy in OVE26 Type 1 Diabetic Mice. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-14.
https://search.emarefa.net/detail/BIM-1205246
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tang, Xiaoqiang& Jiang, Saizhi& Zhang, Jian& Zhou, Shanshan& Zheng, Yang. Sex Differences in Progression of Diabetic Cardiomyopathy in OVE26 Type 1 Diabetic Mice. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1205246
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1205246
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر