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Modulation of Calcium Oxalate Crystal Growth and Protection from Oxidatively Damaged Renal Epithelial Cells of Corn Silk Polysaccharides with Different Molecular Weights
المؤلفون المشاركون
Ouyang, Jian-Ming
Sun, Xin-Yuan
Chen, Jia-Yun
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-19، 19ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-01-22
دولة النشر
مصر
عدد الصفحات
19
التخصصات الرئيسية
الملخص EN
Corn silk polysaccharide (CSP0; molecular weight=124 kDa) was degraded by ultrasonication to obtain five degraded polysaccharides, namely, CSP1, CSP2, CSP3, CSP4, and CSP5, with molecular weights of 26.1, 12.2, 6.0, 3.5, and 2.0 kDa, respectively.
The structures of these polysaccharides were characterized by FT-IR, 1H NMR, and 13C NMR analyses.
The antioxidant activities, including scavenging ability for hydroxyl radicals and DPPH free radicals, chelation ability for Fe2+ ions, and reducing ability of CSP increased with decreased molecular weight of CSPs within 6.0 to 124 kDa.
However, antioxidant activity weakened when the molecular weight of CSPs reached 3.5 and 2 kDa.
CSP3 with a molecular weight of 6.0 kDa exhibited the strongest antioxidant activity.
After protection with 60 μg/mL CSPs, the viability of human renal proximal tubular epithelial cells (HK-2) damaged by nano-COM crystals increased, the level of reactive oxygen species decreased, and the amount of COM crystal adhered onto the cell surface decreased.
The ability of CSPs to protect cells from CaOx crystal damage was consistent with their antioxidant activity.
CSPs can specifically combine with CaOx crystal to inhibit the conversion of calcium oxalate dihydrate crystal to calcium oxalate monohydrate crystal.
All these results showed that the activity of CSPs was closely correlated with molecular weight.
A very high or low molecular weight of CSPs was not conducive to their activity.
CSPs, especially CSP3 with a molecular weight of 6.0 kDa, can be used as a potential antistone drug.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chen, Jia-Yun& Sun, Xin-Yuan& Ouyang, Jian-Ming. 2020. Modulation of Calcium Oxalate Crystal Growth and Protection from Oxidatively Damaged Renal Epithelial Cells of Corn Silk Polysaccharides with Different Molecular Weights. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-19.
https://search.emarefa.net/detail/BIM-1205259
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chen, Jia-Yun…[et al.]. Modulation of Calcium Oxalate Crystal Growth and Protection from Oxidatively Damaged Renal Epithelial Cells of Corn Silk Polysaccharides with Different Molecular Weights. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-19.
https://search.emarefa.net/detail/BIM-1205259
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chen, Jia-Yun& Sun, Xin-Yuan& Ouyang, Jian-Ming. Modulation of Calcium Oxalate Crystal Growth and Protection from Oxidatively Damaged Renal Epithelial Cells of Corn Silk Polysaccharides with Different Molecular Weights. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-19.
https://search.emarefa.net/detail/BIM-1205259
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1205259
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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