Shen Shuai II Recipe Attenuates Apoptosis in 56 Renal AblationInfarction Rats by Inhibiting p53 and the Mitochondrial Pathway of Apoptosis
المؤلفون المشاركون
Wang, Meng
Yang, Jing
Wang, Chen
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-01-23
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Background.
Chronic kidney disease (CKD) is a global health burden with high mortality and morbidity.
Clinical efficacy has been demonstrated for Shen Shuai II Recipe (SSR), an approved and widely used Chinese herbal medicine for over 20 years in China, to attenuate CKD progression.
In this study, we explored the underlying molecular mechanisms of SSR benefits and studied its effects on apoptosis, a critical process in CKD development and progression.
CKD was induced in rats with 5/6 renal ablation and infarction (A/I).
Eight weeks after SSR treatment, we mainly assessed the severity of renal injury and fibrosis, the translocation of apoptotic factors in the mitochondrial apoptosis pathway, the degree of mitochondrial dysfunction, and the nuclear and mitochondrial translocation of p53.
Furthermore, we detected the interaction of p53 with antiapoptotic Bcl-xL and Bcl-2 proteins.
Our results showed that SSR significantly attenuated renal injury and fibrosis and inhibited the mitochondrial accumulation of proapoptotic proteins Bax and Puma and release of cytochrome c from mitochondria to the cytosol in a rat CKD model.
In addition, SSR also improved the mitochondrial function and inhibited the nuclear and mitochondrial translocation of p53.
In addition, SSR suppressed the p53 transactivation and the interaction of p53 with Bcl-xL and Bcl-2.
These results suggested that SSR could block apoptosis in CKD by inhibiting p53 transcriptional-dependent and transcriptional-independent proapoptotic function and the mitochondrial pathway of apoptosis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Meng& Yang, Jing& Wang, Chen. 2020. Shen Shuai II Recipe Attenuates Apoptosis in 56 Renal AblationInfarction Rats by Inhibiting p53 and the Mitochondrial Pathway of Apoptosis. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1205280
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Meng…[et al.]. Shen Shuai II Recipe Attenuates Apoptosis in 56 Renal AblationInfarction Rats by Inhibiting p53 and the Mitochondrial Pathway of Apoptosis. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1205280
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Meng& Yang, Jing& Wang, Chen. Shen Shuai II Recipe Attenuates Apoptosis in 56 Renal AblationInfarction Rats by Inhibiting p53 and the Mitochondrial Pathway of Apoptosis. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1205280
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1205280
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر