Two Faces of Heme Catabolic Pathway in Newborns: A Potential Role of Bilirubin and Carbon Monoxide in Neonatal Inflammatory Diseases
المؤلفون المشاركون
Kurzepa, Jacek
Osiak, Wiktoria
Wątroba, Sławomir
Kapka-Skrzypczak, Lucyna
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-08-18
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
In an infant’s body, all the systems undergo significant changes in order to adapt to the new, extrauterine environment and challenges which it poses.
Fragile homeostasis can be easily disrupted as the defensive mechanisms are yet imperfect.
The activity of antioxidant enzymes, i.e., superoxide dismutase, catalase, and glutathione peroxidase, is low; therefore, neonates are especially vulnerable to oxidative stress.
Free radical burden significantly contributes to neonatal illnesses such as sepsis, retinopathy of premature, necrotizing enterocolitis, bronchopulmonary dysplasia, or leukomalacia.
However, newborns have an important ally—an inducible heme oxygenase-1 (HO-1) which expression rises rapidly in response to stress stimuli.
HO-1 activity leads to production of carbon monoxide (CO), free iron ion, and biliverdin; the latter is promptly reduced to bilirubin.
Although CO and bilirubin used to be considered noxious by-products, new interesting properties of those compounds are being revealed.
Bilirubin proved to be an efficient free radicals scavenger and modulator of immune responses.
CO affects a vast range of processes such as vasodilatation, platelet aggregation, and inflammatory reactions.
Recently, developed nanoparticles consisting of PEGylated bilirubin as well as several kinds of molecules releasing CO have been successfully tested on animal models of inflammatory diseases.
This paper focuses on the role of heme metabolites and their potential utility in prevention and treatment of neonatal diseases.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Osiak, Wiktoria& Wątroba, Sławomir& Kapka-Skrzypczak, Lucyna& Kurzepa, Jacek. 2020. Two Faces of Heme Catabolic Pathway in Newborns: A Potential Role of Bilirubin and Carbon Monoxide in Neonatal Inflammatory Diseases. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1205296
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Osiak, Wiktoria…[et al.]. Two Faces of Heme Catabolic Pathway in Newborns: A Potential Role of Bilirubin and Carbon Monoxide in Neonatal Inflammatory Diseases. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-14.
https://search.emarefa.net/detail/BIM-1205296
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Osiak, Wiktoria& Wątroba, Sławomir& Kapka-Skrzypczak, Lucyna& Kurzepa, Jacek. Two Faces of Heme Catabolic Pathway in Newborns: A Potential Role of Bilirubin and Carbon Monoxide in Neonatal Inflammatory Diseases. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1205296
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1205296
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر