Sodium Tanshinone IIA Sulfonate Attenuates Erectile Dysfunction in Rats with Hyperlipidemia
المؤلفون المشاركون
Zhong, Liren
Ding, Wei
Zeng, Qinyu
He, Binglin
Zhang, Haibo
Wang, Li
Fan, Junhong
He, Shuhua
Zhang, Yuanyuan
Wei, Anyang
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-03-07
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Hyperlipidemia is considered one of the most important risk factors for erectile dysfunction (ED).
To determine the effect of sodium tanshinone IIA sulfonate (STS) as an antioxidant agent on ED in high-fat diet- (HFD-) induced hyperlipidemia in rats and to investigate if STS administration could improve erectile function via hydrogen sulfide (H2S) production by inhibition of oxidative stress.
Hyperlipidemia was induced in Sprague-Dawley rats by feeding HFD for 16 weeks.
The rats were randomly divided into 3 groups: control, HFD, and HFD treated with STS (10 mg/kg/day for 12 weeks, intraperitoneal injection).
Erectile function including intracavernosal pressure (ICP), H2S production, and antioxidant capacity was assessed.
In addition, cavernosal smooth muscle cells (CSMC) isolated from SD rats were pretreated with STS in vitro and exposed to H2O2.
Expressions of nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1), activity of antioxidant enzymes, and H2S-generating enzymes within CSMC were examined.
ICP was significantly decreased in HFD rats compared with control.
In addition, decreased H2S production and expression of cystathionine ɣ-lyase (CSE) and cystathionine β-synthase (CBS) associated with increased oxidative stress were observed in the penile tissue of HFD rats.
However, all these changes were reversed by 16 weeks after STS administration.
STS also increased antioxidant defense as evidenced by increased expression of Nrf2/HO-1 in the penile tissue of HFD rats.
In CSMC, pretreatment with STS attenuated the decreased expression of CSE and CBS and H2S production by H2O2.
STS exerted similar protective antioxidative effect as shown in the in vivo hyperlipidemia model.
The present study demonstrated the redox effect of STS treatment on ED via increased H2S production in HFD-induced hyperlipidemia rat model by increased antioxidant capacity via activation of the Nrf2/HO-1 pathway, which provides STS potential clinical application in the treatment of hyperlipidemia-related ED.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhong, Liren& Ding, Wei& Zeng, Qinyu& He, Binglin& Zhang, Haibo& Wang, Li…[et al.]. 2020. Sodium Tanshinone IIA Sulfonate Attenuates Erectile Dysfunction in Rats with Hyperlipidemia. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1205328
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhong, Liren…[et al.]. Sodium Tanshinone IIA Sulfonate Attenuates Erectile Dysfunction in Rats with Hyperlipidemia. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1205328
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhong, Liren& Ding, Wei& Zeng, Qinyu& He, Binglin& Zhang, Haibo& Wang, Li…[et al.]. Sodium Tanshinone IIA Sulfonate Attenuates Erectile Dysfunction in Rats with Hyperlipidemia. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1205328
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1205328
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر