Protection against Doxorubicin-Induced Cytotoxicity by Geniposide Involves AMPKα Signaling Pathway
المؤلفون المشاركون
Tang, Qi-Zhu
Ma, Zhen-Guo
Meng, Yan-yan
Yuan, Yu-Pei
Zhang, Xin
Kong, Chun-Yan
Song, Peng
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-06-26
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Oxidative stress and cardiomyocyte apoptosis play critical roles in the development of doxorubicin- (DOX-) induced cardiotoxicity.
Our previous study found that geniposide (GE) could inhibit cardiac oxidative stress and apoptosis of cardiomyocytes but its role in DOX-induced heart injury remains unknown.
Our study is aimed at investigating whether GE could protect against DOX-induced heart injury.
The mice were subjected to a single intraperitoneal injection of DOX (15 mg/kg) to induce cardiomyopathy model.
To explore the protective effects, GE was orally given for 10 days.
The morphological examination and biochemical analysis were used to evaluate the effects of GE.
H9C2 cells were used to verify the protective role of GE in vitro.
GE treatment alleviated heart dysfunction and attenuated cardiac oxidative stress and cell loss induced by DOX in vivo and in vitro.
GE could activate AMP-activated protein kinase α (AMPKα) in vivo and in vitro.
Moreover, inhibition of AMPKα could abolish the protective effects of GE against DOX-induced oxidative stress and apoptosis.
GE could protect against DOX-induced heart injury via activation of AMPKα.
GE has therapeutic potential for the treatment of DOX cardiotoxicity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Meng, Yan-yan& Yuan, Yu-Pei& Zhang, Xin& Kong, Chun-Yan& Song, Peng& Ma, Zhen-Guo…[et al.]. 2019. Protection against Doxorubicin-Induced Cytotoxicity by Geniposide Involves AMPKα Signaling Pathway. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1205339
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Meng, Yan-yan…[et al.]. Protection against Doxorubicin-Induced Cytotoxicity by Geniposide Involves AMPKα Signaling Pathway. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1205339
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Meng, Yan-yan& Yuan, Yu-Pei& Zhang, Xin& Kong, Chun-Yan& Song, Peng& Ma, Zhen-Guo…[et al.]. Protection against Doxorubicin-Induced Cytotoxicity by Geniposide Involves AMPKα Signaling Pathway. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1205339
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1205339
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر