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Nutritional Preconditioning of Apigenin Alleviates Myocardial IschemiaReperfusion Injury via the Mitochondrial Pathway Mediated by Notch1Hes1
المؤلفون المشاركون
Luo, Yong
Huang, Huang
Lai, Songqing
Wan, Qing
Wu, Qicai
Wan, Li
Qi, Wanghong
Liu, Jichun
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-03-20
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
Apigenin (Api), a natural flavone found in high amounts in several herbs, has shown potent cardioprotective effects in clinical studies, although the underlying mechanisms are not clear.
We hypothesized that Api protects the myocardium from simulated ischemia/reperfusion (SI/R) injury via nutritional preconditioning (NPC).
Rats fed with Api-containing food showed improvement in cardiac functions; lactate dehydrogenase (LDH) and creatine phosphokinase (CPK) activities; infarct size; apoptosis rates; malondialdehyde (MDA) levels; caspase-3, superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase (CAT) activities; and ferric reducing antioxidant power (FRAP) compared to those fed standard chow following SI/R injury.
In addition, Api pretreatment significantly improved the viability, decreased the LDH activity and intracellular reactive oxygen species (ROS) generation, alleviated the loss of mitochondrial membrane potential (MMP), prevented the opening of the mitochondrial permeability transition pore (mPTP), and decreased the caspase-3 activity, cytochrome c (Cyt C) release, and apoptosis induced by SI/R in primary cardiomyocytes.
Mechanistically, Api upregulated Hes1 expression and was functionally neutralized by the Notch1 γ-secretase inhibitor GSI, as well as the mPTP opener atractyloside (Atr).
Taken together, Api protected the myocardium against SI/R injury via the mitochondrial pathway mediated by the Notch1/Hes1 signaling pathway.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Huang, Huang& Lai, Songqing& Luo, Yong& Wan, Qing& Wu, Qicai& Wan, Li…[et al.]. 2019. Nutritional Preconditioning of Apigenin Alleviates Myocardial IschemiaReperfusion Injury via the Mitochondrial Pathway Mediated by Notch1Hes1. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1205384
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Huang, Huang…[et al.]. Nutritional Preconditioning of Apigenin Alleviates Myocardial IschemiaReperfusion Injury via the Mitochondrial Pathway Mediated by Notch1Hes1. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-15.
https://search.emarefa.net/detail/BIM-1205384
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Huang, Huang& Lai, Songqing& Luo, Yong& Wan, Qing& Wu, Qicai& Wan, Li…[et al.]. Nutritional Preconditioning of Apigenin Alleviates Myocardial IschemiaReperfusion Injury via the Mitochondrial Pathway Mediated by Notch1Hes1. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1205384
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1205384
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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