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Decrypting the Molecular Mechanistic Pathways Delineating the Chemotherapeutic Potential of Ruthenium-Phloretin Complex in Colon Carcinoma Correlated with the Oxidative Status and Increased Apoptotic Events
المؤلفون المشاركون
Jin, Guoguo
Zhao, Zhenjiang
Chakraborty, Tania
Mandal, Aikyadeep
Roy, Arka
Guo, Zhiping
Roy, Souvik
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-24، 24ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-05-31
دولة النشر
مصر
عدد الصفحات
24
التخصصات الرئيسية
الملخص EN
To explore fresh strategies in colorectal cancer (CRC) chemotherapy, we evaluated the capability of the ruthenium-phloretin complex in exterminating colon cancer by effectively addressing multiple apoptotic mechanisms on HT-29 cancer cells together with an animal model of colorectal cancer activated by 1,2-dimethylhydrazine and dextran sulfate sodium.
Our current approach offers tangible evidence of the application of the ruthenium-phloretin complex in future chemotherapy.
The complex triggers intrinsic apoptosis triggered by p53 and modulates the Akt/mTOR pathway along with other inflammatory biomarkers.
The ruthenium-phloretin complex has been synthesized and successfully characterized by numerous spectroscopic methodologies accompanied by DPPH, FRAP, and ABTS assays assessing its antioxidant potential.
Studies conducted in human cell lines revealed that the complex improved levels of p53 and caspase-3 while diminishing the activities of VEGF and mTOR, triggers apoptosis, and induces fragmentation of DNA in the HT-29 cells.
Toxicity studies were conducted to identify the therapeutic doses of the novel complex in animal models.
The outcomes of the in vivo report suggest that the complex was beneficial in repressing multiplicity of aberrant crypt foci as well as hyperplastic lesions and also promoted increased levels of CAT, SOD, and glutathione.
In addition, the ruthenium-phloretin complex was able to control cell proliferation and boosted apoptotic outbursts in cancer cells associated with the increase in cellular response towards Bax while diminishing responses towards Bcl-2, NF-κB, and MMP-9.
Our observations from the experiments deliver testament that the ruthenium-phloretin complex has the potential to act as a promising chemotherapeutic agent in colorectal cancer because it can affect the growth of ACF and hyperplastic abrasions in the colon tissues by evoking cell death.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jin, Guoguo& Zhao, Zhenjiang& Chakraborty, Tania& Mandal, Aikyadeep& Roy, Arka& Roy, Souvik…[et al.]. 2020. Decrypting the Molecular Mechanistic Pathways Delineating the Chemotherapeutic Potential of Ruthenium-Phloretin Complex in Colon Carcinoma Correlated with the Oxidative Status and Increased Apoptotic Events. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-24.
https://search.emarefa.net/detail/BIM-1205422
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jin, Guoguo…[et al.]. Decrypting the Molecular Mechanistic Pathways Delineating the Chemotherapeutic Potential of Ruthenium-Phloretin Complex in Colon Carcinoma Correlated with the Oxidative Status and Increased Apoptotic Events. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-24.
https://search.emarefa.net/detail/BIM-1205422
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jin, Guoguo& Zhao, Zhenjiang& Chakraborty, Tania& Mandal, Aikyadeep& Roy, Arka& Roy, Souvik…[et al.]. Decrypting the Molecular Mechanistic Pathways Delineating the Chemotherapeutic Potential of Ruthenium-Phloretin Complex in Colon Carcinoma Correlated with the Oxidative Status and Increased Apoptotic Events. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-24.
https://search.emarefa.net/detail/BIM-1205422
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1205422
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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