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IgG-Dependent Dismutation of Superoxide in Patients with Different Types of Multiple Sclerosis and Healthy Subjects
المؤلفون المشاركون
Ivanova, Svetlana A.
Smirnova, Liudmila P.
Mednova, Irina A.
Krotenko, Nina M.
Alifirova, Valentina M.
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-02-05
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
This work is the first to demonstrate that class G immunoglobulins (IgGs) in patients with multiple sclerosis and healthy individuals have the ability to catalyze the dismutation reaction of the superoxide anion radical.
Thus, superoxide dismutase (SOD) activity is an intrinsic property of antibodies, which is confirmed by a number of stringent criteria.
SOD activity of IgGs in patients with multiple sclerosis statistically significantly exceeds such activity in healthy individuals by 2-4 times.
Moreover, the maximum activity has been registered in patients with relapsing remitting multiple sclerosis.
The kinetic characteristics of the SOD reaction of IgGs are several orders of magnitude lower than those for the SOD enzyme but do not differ between patients with multiple sclerosis and healthy individuals.
Consequently, abzymes with SOD activity have a lower catalysis rate than that of the enzymes and form a stronger complex with the substrates.
Inhibitory analysis showed that this activity is inhibited by classical metal-dependent SOD inhibitors.
The activity of IgGs was inhibited by classical metal-dependent inhibitors EDTA and TETA (triethylenetetramine).
Also, high catalase activity of IgGs was detected in these patients.
We suggest that these abzymes help protect the body from oxidative stress.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Smirnova, Liudmila P.& Mednova, Irina A.& Krotenko, Nina M.& Alifirova, Valentina M.& Ivanova, Svetlana A.. 2020. IgG-Dependent Dismutation of Superoxide in Patients with Different Types of Multiple Sclerosis and Healthy Subjects. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1205529
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Smirnova, Liudmila P.…[et al.]. IgG-Dependent Dismutation of Superoxide in Patients with Different Types of Multiple Sclerosis and Healthy Subjects. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1205529
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Smirnova, Liudmila P.& Mednova, Irina A.& Krotenko, Nina M.& Alifirova, Valentina M.& Ivanova, Svetlana A.. IgG-Dependent Dismutation of Superoxide in Patients with Different Types of Multiple Sclerosis and Healthy Subjects. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1205529
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1205529
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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