Systems Pharmacology and Microbiome Dissection of Shen Ling Bai Zhu San Reveal Multiscale Treatment Strategy for IBD
المؤلفون المشاركون
Xu, Xiaolong
Liu, Cui
Lv, Weijie
Chao, Limin
Guo, Shining
Li, Yue
Xiong, Ying
Chen, Wen-qian
Li, Yue-fei
Li, Zeng-quan
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-30، 30ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-06-23
دولة النشر
مصر
عدد الصفحات
30
التخصصات الرئيسية
الملخص EN
Generally, inflammatory bowel disease (IBD) can be caused by psychology, genes, environment, and gut microbiota.
Therefore, IBD therapy should be improved to utilize multiple strategies.
Shen Ling Bai Zhu San (SLBZS) adheres to the aim of combating complex diseases from an integrative and holistic perspective, which is effective for IBD therapy.
Herein, a systems pharmacology and microbiota approach was developed for these molecular mechanisms exemplified by SLBZS.
First, by systematic absorption-distribution-metabolism-excretion (ADME) analysis, potential active compounds and their corresponding direct targets were retrieved.
Then, the network relationships among the active compounds, targets, and disease were built to deduce the pharmacological actions of the drug.
Finally, an “IBD pathway” consisting of several regulatory modules was proposed to dissect the therapeutic effects of SLBZS.
In addition, the effects of SLBZS on gut microbiota were evaluated through analysis of the V3-V4 region and multivariate statistical methods.
SLBZS significantly shifted the gut microbiota structure in a rat model.
Taken together, we found that SLBZS has multidimensionality in the regulation of IBD-related physiological processes, which provides new sights into herbal medicine for the treatment of IBD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lv, Weijie& Liu, Cui& Li, Yue-fei& Chen, Wen-qian& Li, Zeng-quan& Li, Yue…[et al.]. 2019. Systems Pharmacology and Microbiome Dissection of Shen Ling Bai Zhu San Reveal Multiscale Treatment Strategy for IBD. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-30.
https://search.emarefa.net/detail/BIM-1205537
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lv, Weijie…[et al.]. Systems Pharmacology and Microbiome Dissection of Shen Ling Bai Zhu San Reveal Multiscale Treatment Strategy for IBD. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-30.
https://search.emarefa.net/detail/BIM-1205537
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lv, Weijie& Liu, Cui& Li, Yue-fei& Chen, Wen-qian& Li, Zeng-quan& Li, Yue…[et al.]. Systems Pharmacology and Microbiome Dissection of Shen Ling Bai Zhu San Reveal Multiscale Treatment Strategy for IBD. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-30.
https://search.emarefa.net/detail/BIM-1205537
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1205537
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر