FA-97, a New Synthetic Caffeic Acid Phenethyl Ester Derivative, Protects against Oxidative Stress-Mediated Neuronal Cell Apoptosis and Scopolamine-Induced Cognitive Impairment by Activating Nrf2HO-1 Signaling
المؤلفون المشاركون
Wang, Qi
Li, Wei-Rong
Mei, Yu
Wan, Ting
Wang, Zihao
Luo, Yi
Zhang, Yifan
He, Wei
Xue, Jincheng
Li, Min
Pan, Huafeng
Huang, Yujie
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-21، 21ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-12-03
دولة النشر
مصر
عدد الصفحات
21
التخصصات الرئيسية
الملخص EN
Alzheimer’s disease (AD) is an age-related neurodegenerative disorder with cognitive deficits, which is becoming markedly more common in the world.
Currently, the exact cause of AD is still unclear, and no curative therapy is available for preventing or mitigating the disease progression.
Caffeic acid phenethyl ester (CAPE), a natural phenolic compound derived from honeybee hive propolis, has been reported as a potential therapeutic agent against AD, while its application is limited due to the low water solubility and poor bioavailability.
Here, caffeic acid phenethyl ester 4-O-glucoside (FA-97) is synthesized.
We validate that FA-97 attenuates H2O2-induced apoptosis in SH-SY5Y and PC12 cells and suppresses H2O2-induced oxidative stress by inhibiting the ROS level, malondialdehyde (MDA) level, and protein carbonylation level, as well as induces cellular glutathione (GSH) and superoxide dismutase (SOD).
Mechanistically, FA-97 promotes the nuclear translocation and transcriptional activity of Nrf2 associated with the upregulated expression of HO-1 and NQO-1.
The prime importance of Nrf2 activation in the neuroprotective and antioxidant effects of FA-97 is verified by Nrf2 siRNA transfection.
In addition, FA-97 prevents scopolamine- (SCOP-) induced learning and memory impairments in vivo via reducing neuronal apoptosis and protecting against cholinergic system dysfunction in the hippocampus and cortex.
Moreover, the increased MDA level and low total antioxidant capacity in SCOP-treated mouse brains are reversed by FA-97, with the increased expression of HO-1, NQO-1, and nuclear Nrf2.
In conclusion, FA-97 protects against oxidative stress-mediated neuronal cell apoptosis and SCOP-induced cognitive impairment by activating Nrf2/HO-1 signaling, which might be developed as a therapeutic drug for AD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wan, Ting& Wang, Zihao& Luo, Yi& Zhang, Yifan& He, Wei& Mei, Yu…[et al.]. 2019. FA-97, a New Synthetic Caffeic Acid Phenethyl Ester Derivative, Protects against Oxidative Stress-Mediated Neuronal Cell Apoptosis and Scopolamine-Induced Cognitive Impairment by Activating Nrf2HO-1 Signaling. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-21.
https://search.emarefa.net/detail/BIM-1205561
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wan, Ting…[et al.]. FA-97, a New Synthetic Caffeic Acid Phenethyl Ester Derivative, Protects against Oxidative Stress-Mediated Neuronal Cell Apoptosis and Scopolamine-Induced Cognitive Impairment by Activating Nrf2HO-1 Signaling. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-21.
https://search.emarefa.net/detail/BIM-1205561
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wan, Ting& Wang, Zihao& Luo, Yi& Zhang, Yifan& He, Wei& Mei, Yu…[et al.]. FA-97, a New Synthetic Caffeic Acid Phenethyl Ester Derivative, Protects against Oxidative Stress-Mediated Neuronal Cell Apoptosis and Scopolamine-Induced Cognitive Impairment by Activating Nrf2HO-1 Signaling. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-21.
https://search.emarefa.net/detail/BIM-1205561
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1205561
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر