Effect of Indigofera oblongifolia on the Hepatic Oxidative Status and Expression of Inflammatory and Apoptotic Genes during Blood-Stage Murine Malaria

المؤلفون المشاركون

Dkhil, Muhammad A.
Al-Shaebi, Esam M.
al-Quraishy, Salih

المصدر

Oxidative Medicine and Cellular Longevity

العدد

المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-7، 7ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2019-01-29

دولة النشر

مصر

عدد الصفحات

7

التخصصات الرئيسية

الأحياء

الملخص EN

Malaria is a dangerous disease spread across several countries.

Recent studies have focused on medicinal plants to discover alternative agents to the currently used drugs for malaria treatment.

Here, we investigated the potential role of Indigofera oblongifolia leaf extract (IE) on hepatic inflammation in mice with Plasmodium chabaudi-infected erythrocytes.

Female C57BL/6 mice were divided into three groups.

The first group served as a control noninfected group, while the second and third groups were intraperitoneally injected with 106 erythrocytes parasitized by P.

chabaudi.

Mice from the third group were treated daily with a dose of 100 mg/kg of IE for 7 days.

IE significantly reduced the number of leukocytes and apoptotic cells.

The numbers of CD68-positive cells decreased in the livers of mice from the treatment group.

Moreover, IE raised the hepatic antioxidant levels (glutathione and catalase) and reduced the levels of hepatic oxidative stress markers (malondialdehyde, nitric oxide, and reactive oxygen species).

IE regulated some functions of the genes related to immune responses, including apoptotic genes (B-cell lymphoma-2, Bax, and caspase-3) and cytokine genes (interleukin-1β (IL-1β), IL-6, interferon-γ, and tumor necrosis factor-α).

Therefore, IE exerts significant effects against malaria and protects the liver from injury caused by P.

chabaudi via antioxidant and anti-inflammatory ways.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Dkhil, Muhammad A.& Al-Shaebi, Esam M.& al-Quraishy, Salih. 2019. Effect of Indigofera oblongifolia on the Hepatic Oxidative Status and Expression of Inflammatory and Apoptotic Genes during Blood-Stage Murine Malaria. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1205580

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Dkhil, Muhammad A.…[et al.]. Effect of Indigofera oblongifolia on the Hepatic Oxidative Status and Expression of Inflammatory and Apoptotic Genes during Blood-Stage Murine Malaria. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1205580

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Dkhil, Muhammad A.& Al-Shaebi, Esam M.& al-Quraishy, Salih. Effect of Indigofera oblongifolia on the Hepatic Oxidative Status and Expression of Inflammatory and Apoptotic Genes during Blood-Stage Murine Malaria. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1205580

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1205580