Vanillic Acid Alleviates Acute Myocardial HypoxiaReoxygenation Injury by Inhibiting Oxidative Stress
المؤلفون المشاركون
Liu, Dan
Yao, Xiuya
Jiao, Shoufeng
Qin, Mingming
Hu, Wenfeng
Yi, Bo
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-04-21
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Oxidative stress is an important factor of myocardial hypoxia/reoxygenation (H/R) injury.
Our research focuses on how to reduce the cardiac toxicity caused by oxidative stress through natural plant extracts.
Vanillic acid (VA) is a phenolic compound found in edible plants and rich in the roots of Angelica sinensis.
Experimental studies have provided evidence for this compound’s effectiveness in cardiovascular diseases; however, its mechanism is still unclear.
In this study, molecular mechanisms related to the protective effects of VA were investigated in H9c2 cells in the context of H/R injury.
The results showed that pretreatment with VA significantly increased cell viability and decreased the percentage of apoptotic cells, as well as lactate dehydrogenase and creatine phosphokinase activity, in the supernatant, accompanied by reduced levels of reactive oxygen species and reduced caspase-3 activity.
VA pretreatment also restored mitochondrial membrane potentials.
Moreover, preincubation with VA significantly attenuated mitochondrial permeability transition pore activity.
VA administration upregulated adenosine monophosphate-activated protein kinase α2 (AMPKα2) protein expression, and interestingly, pretreatment with AMPKα2-siRNA lentivirus effectively attenuated the cardioprotective effects of VA in response to H/R injury.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yao, Xiuya& Jiao, Shoufeng& Qin, Mingming& Hu, Wenfeng& Yi, Bo& Liu, Dan. 2020. Vanillic Acid Alleviates Acute Myocardial HypoxiaReoxygenation Injury by Inhibiting Oxidative Stress. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1205582
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yao, Xiuya…[et al.]. Vanillic Acid Alleviates Acute Myocardial HypoxiaReoxygenation Injury by Inhibiting Oxidative Stress. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1205582
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yao, Xiuya& Jiao, Shoufeng& Qin, Mingming& Hu, Wenfeng& Yi, Bo& Liu, Dan. Vanillic Acid Alleviates Acute Myocardial HypoxiaReoxygenation Injury by Inhibiting Oxidative Stress. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1205582
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1205582
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر