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Antioxidant Defense, Oxidative Modification, and Salivary Gland Function in an Early Phase of Cerulein Pancreatitis
المؤلفون المشاركون
Maciejczyk, M.
Matczuk, J.
Waszkiel, D.
Zalewska, A.
Skutnik-Radziszewska, Anna
Zieniewska, Izabela
Domel, Emilia
Szarmach, Izabela
Żendzian-Piotrowska, Małgorzata
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-03-10
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Acute pancreatitis (AP) is a multifactorial disease characterized by necroinflammatory changes of the pancreas.
Our study is the first study which evaluated the relationship between the free radical production, enzymatic and nonenzymatic antioxidants, oxidative damage, and secretory function of the salivary glands of AP rats.
Male Wistar rats were divided equally into 2 groups: control (n=9) and AP (n=9).
AP was induced by intraperitoneal injection with cerulein and confirmed by higher serum amylase and lipase.
We have demonstrated that the superoxide dismutase and glutathione reductase activities, as well as reduced glutathione concentration, were significantly decreased in both the parotid and submandibular glands of AP rats as compared to the control rats.
The production of free radicals evidenced as dichlorodihydrofluorescein assay and the activity of NADPH oxidase and xanthine oxidase and IL-1β concentration were significantly higher in the parotid and submandibular glands of AP rats compared to the controls.
In AP rats, we also showed a statistical increase in oxidation modification products (advanced glycation end products and advanced oxidation protein products), salivary amylase activity, and significant decrease in the total protein content.
However, we did not show apoptosis and any morphological changes in the histological examination of the salivary glands of AP rats.
To sum up, cerulein-induced AP intensifies production of oxygen free radicals, impairs the redox balance of the salivary glands, and is responsible for higher oxidative damage to these glands.
Interestingly, oxidative modification of proteins and dysfunction of the antioxidant barrier are more pronounced in the submandibular glands of AP rats.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Maciejczyk, M.& Skutnik-Radziszewska, Anna& Zieniewska, Izabela& Matczuk, J.& Domel, Emilia& Waszkiel, D.…[et al.]. 2019. Antioxidant Defense, Oxidative Modification, and Salivary Gland Function in an Early Phase of Cerulein Pancreatitis. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1205642
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Maciejczyk, M.…[et al.]. Antioxidant Defense, Oxidative Modification, and Salivary Gland Function in an Early Phase of Cerulein Pancreatitis. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-14.
https://search.emarefa.net/detail/BIM-1205642
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Maciejczyk, M.& Skutnik-Radziszewska, Anna& Zieniewska, Izabela& Matczuk, J.& Domel, Emilia& Waszkiel, D.…[et al.]. Antioxidant Defense, Oxidative Modification, and Salivary Gland Function in an Early Phase of Cerulein Pancreatitis. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1205642
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1205642
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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