β-Lapachone Increases Survival of Septic Mice by Regulating Inflammatory and Oxidative Response
المؤلفون المشاركون
de B. Oliveira, Ana L.
Navegantes-Lima, Kely C.
Monteiro, Valter V. S.
Quadros, Lucas B. G.
de Oliveira, Juliana P.
dos Santos, Sávio M.
de A. Pontes, Anna C. A.
Dorneles, Gilson P.
Júnior, Luiz C. R.
de Oliveira, Alaíde B.
Monteiro, Marta C.
Romão, Pedro R. T.
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-12-12
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Sepsis is characterized by a dysregulated immune response to infection characterized by an early hyperinflammatory and oxidative response followed by a subsequent immunosuppression phase.
Although there have been some advances in the treatment of sepsis, mortality rates remain high, urging for the search of new therapies.
β-Lapachone (β-Lap) is a natural compound obtained from Tabebuia avellanedae Lorentz ex Griseb.
with several pharmacological properties including bactericidal, anti-inflammatory, and antioxidant activity.
Thus, the aim of this study was to evaluate the effects of β-Lap in a mouse sepsis model.
To this, we tested two therapeutic protocols in mice submitted to cecal ligation and puncture- (CLP-) induced sepsis.
First, we found that in pretreated animals, β-Lap reduced the systemic inflammatory response and improved bacterial clearance and mouse survival.
Moreover, β-Lap also decreased lipid peroxidation and increased the total antioxidant capacity in the serum and peritoneal cavity of septic animals.
In the model of severe sepsis, the posttreatment with β-Lap was able to increase the survival of animals and maintain the antioxidant defense function.
In conclusion, the β-Lap was able to increase the survival of septic animals by a mechanism involving immunomodulatory and antioxidant protective effects.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
de B. Oliveira, Ana L.& Navegantes-Lima, Kely C.& Monteiro, Valter V. S.& Quadros, Lucas B. G.& de Oliveira, Juliana P.& dos Santos, Sávio M.…[et al.]. 2020. β-Lapachone Increases Survival of Septic Mice by Regulating Inflammatory and Oxidative Response. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1205722
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
de B. Oliveira, Ana L.…[et al.]. β-Lapachone Increases Survival of Septic Mice by Regulating Inflammatory and Oxidative Response. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1205722
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
de B. Oliveira, Ana L.& Navegantes-Lima, Kely C.& Monteiro, Valter V. S.& Quadros, Lucas B. G.& de Oliveira, Juliana P.& dos Santos, Sávio M.…[et al.]. β-Lapachone Increases Survival of Septic Mice by Regulating Inflammatory and Oxidative Response. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1205722
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1205722
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر