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Effect of Zinc on the Oxidative Stress Biomarkers in the Brain of Nickel-Treated Mice
المؤلفون المشاركون
Kasauskas, Arturas
Šulinskienė, Jurgita
Bernotienė, Rasa
Baranauskienė, Dalė
Naginienė, Rima
Stanevičienė, Inga
Ivanov, Leonid
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-09-02
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
The overexposure to nickel due to the extensive use of it in modern technology remains a major public health concern.
The mechanisms of pathological effects of this metal remain elusive.
The present study was devoted to evaluate the effect of nickel on the oxidative state of the brain cells of mice and to assess whether zinc as redox state modulator could efficiently protect cells against nickel’s neurotoxicity.
As oxidative stress biomarkers in the present study, we have measured the concentrations of reduced glutathione, metallothioneins, and malondialdehyde and the activity of the enzyme δ-aminolevulinate dehydratase.
For the single metal exposure, mice were i.p.
injected once with solutions of NiCl2 and/or ZnSO4; repeated exposure was performed i.p.
injecting metal salt solutions for 14 days (once a day).
The control mice received i.p.
injections of saline.
Results of our study demonstrate that single and 14 days of Ni2+ exposure decreased reduced glutathione and increased malondialdehyde contents in the brain of mice.
Repeated Ni2+ administration significantly inhibited δ-aminolevulinate dehydratase while increasing brain metallothionein concentration at both exposure periods.
Zinc exhibited a protective effect against nickel-induced glutathione and lipid peroxidation in brain cells of mice at both intervals of time, while repeated exposure to this metal significantly raised the brain metallothionein content.
Repeated Zn2+ pretreatment protected δ-aminolevulinate dehydratase from Ni2+-induced inhibition and significantly increased metallothionein concentration at both investigated time intervals.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Šulinskienė, Jurgita& Bernotienė, Rasa& Baranauskienė, Dalė& Naginienė, Rima& Stanevičienė, Inga& Kasauskas, Arturas…[et al.]. 2019. Effect of Zinc on the Oxidative Stress Biomarkers in the Brain of Nickel-Treated Mice. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1205759
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Šulinskienė, Jurgita…[et al.]. Effect of Zinc on the Oxidative Stress Biomarkers in the Brain of Nickel-Treated Mice. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1205759
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Šulinskienė, Jurgita& Bernotienė, Rasa& Baranauskienė, Dalė& Naginienė, Rima& Stanevičienė, Inga& Kasauskas, Arturas…[et al.]. Effect of Zinc on the Oxidative Stress Biomarkers in the Brain of Nickel-Treated Mice. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1205759
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1205759
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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