Antioxidant and α-Glucosidase Inhibitory Activities Guided Isolation and Identification of Components from Mango Seed Kernel
المؤلفون المشاركون
Zhai, Jianxiu
Han, Na
Chen, Xuee
Liu, Xida
Liu, Zhihui
Li, Sikai
Yin, Jun
Yang, Dan
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-12-29
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
In the present study, petroleum ether, dichloromethane, ethyl acetate, and n-butanol fractions of mango seed kernel exhibited different degrees of antioxidant and α-glucosidase inhibitory activity.
Thus, quantitative and qualitative analysis of the petroleum ether fraction was conducted by GC-MS.
Among identified components, four unsaturated fatty acids had never been reported in natural products before, together with 19 known components.
In addition, 17 compounds were isolated and elucidated from other active fractions.
Compounds 2, 9, 15, and 17 were isolated for the first time from Mangifera genus.
Compounds 1 and 2 exhibited prominent DPPH radical scavenging and α-glucosidase inhibitory effects.
In order to further explore their mechanism of α-glucosidase inhibition, their enzyme kinetics and in silico modeling experiments were performed.
The results indicated that 1 inhibited α-glucosidase in a noncompetitive manner, whereas 2 acted in a competitive manner.
In molecular docking, the stability of binding was enhanced by π-π T-shaped, π-alkyl, π-π stacked, hydrogen bond, and electrostatic interactions.
Thus, compounds 1 and 2 were determined to be new potent antioxidant and α-glucosidase inhibitors for preventing food oxidation and enhancing hypoglycemic activity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yang, Dan& Chen, Xuee& Liu, Xida& Han, Na& Liu, Zhihui& Li, Sikai…[et al.]. 2020. Antioxidant and α-Glucosidase Inhibitory Activities Guided Isolation and Identification of Components from Mango Seed Kernel. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1205791
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yang, Dan…[et al.]. Antioxidant and α-Glucosidase Inhibitory Activities Guided Isolation and Identification of Components from Mango Seed Kernel. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-15.
https://search.emarefa.net/detail/BIM-1205791
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yang, Dan& Chen, Xuee& Liu, Xida& Han, Na& Liu, Zhihui& Li, Sikai…[et al.]. Antioxidant and α-Glucosidase Inhibitory Activities Guided Isolation and Identification of Components from Mango Seed Kernel. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1205791
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1205791
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر