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What Is the Impact of Depletion of Immunoregulatory Genes on Wound Healing? A Systematic Review of Preclinical Evidence
المؤلفون المشاركون
Sarandy, Mariáurea M.
Gonçalves, Reggiani Vilela
Novaes, Rômulo Dias
Nogueira, Bárbara Cristina Félix
Campos, Artur Kanadani
Alves, Raul Santos
Esposito, Debora
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-19، 19ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-12-07
دولة النشر
مصر
عدد الصفحات
19
التخصصات الرئيسية
الملخص EN
Cytokines and growth factors are known to play an important role in the skin wound closure process; however, in knockout organisms, the levels of these molecules can undergo changes that result in the delay or acceleration of this process.
Therefore, we systematically reviewed evidence from preclinical studies about the main immunoregulatory molecules involved in skin repair through the analysis of the main mechanisms involved in the depletion of immunoregulatory genes, and we carried out a critical analysis of the methodological quality of these studies.
We searched biomedical databases, and only original studies were analyzed according to the PRISMA guidelines.
The included studies were limited to those which used knockout animals and excision or incision wound models without intervention.
A total of 27 studies were selected; data for animal models, gene depletion, wound characteristics, and immunoregulatory molecules were evaluated and compared whenever possible.
Methodological quality assessments were examined using the ARRIVE and SYRCLE’s bias of risk tool.
In our review, the extracellular molecules act more negatively in the wound healing process when silenced and the metabolic pathway most affected involved in these processes was TGF-β/Smad, and emphasis was given to the importance of the participation of macrophages in TGF-β signaling.
Besides that, proinflammatory molecules were more evaluated than anti-inflammatory ones, and the main molecules evaluated were, respectively, TGF-β1, followed by VEGF, IL-6, TNF-α, and IL-1β.
Overall, most gene depletions delayed wound healing, negatively influenced the concentrations of proinflammatory cytokines, and consequently promoted a decrease of inflammatory cell infiltration, angiogenesis, and collagen deposition, compromising the formation of granulation tissue.
The studies presented heterogeneous data and exhibited methodological limitations; therefore, mechanistic and highly controlled studies are required to improve the quality of the evidence.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Nogueira, Bárbara Cristina Félix& Campos, Artur Kanadani& Alves, Raul Santos& Sarandy, Mariáurea M.& Novaes, Rômulo Dias& Esposito, Debora…[et al.]. 2020. What Is the Impact of Depletion of Immunoregulatory Genes on Wound Healing? A Systematic Review of Preclinical Evidence. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-19.
https://search.emarefa.net/detail/BIM-1205799
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Nogueira, Bárbara Cristina Félix…[et al.]. What Is the Impact of Depletion of Immunoregulatory Genes on Wound Healing? A Systematic Review of Preclinical Evidence. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-19.
https://search.emarefa.net/detail/BIM-1205799
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Nogueira, Bárbara Cristina Félix& Campos, Artur Kanadani& Alves, Raul Santos& Sarandy, Mariáurea M.& Novaes, Rômulo Dias& Esposito, Debora…[et al.]. What Is the Impact of Depletion of Immunoregulatory Genes on Wound Healing? A Systematic Review of Preclinical Evidence. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-19.
https://search.emarefa.net/detail/BIM-1205799
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1205799
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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