Hydrogen Sulfide Protects Retinal Pigment Epithelial Cells from Oxidative Stress-Induced Apoptosis and Affects Autophagy
المؤلفون المشاركون
Hu, Liming
Guo, Jia
Zhou, Li
Zhu, Sen
Wang, Chunming
Liu, Jiawei
Hu, Shanshan
Yang, Mulin
Lin, Changjun
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-12-31
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
Age-related macular degeneration (AMD) is a major cause of visual impairment and blindness among the elderly.
AMD is characterized by retinal pigment epithelial (RPE) cell dysfunction.
However, the pathogenesis of AMD is still unclear, and there is currently no effective treatment.
Accumulated evidence indicates that oxidative stress and autophagy play a crucial role in the development of AMD.
H2S is an antioxidant that can directly remove intracellular superoxide anions and hydrogen peroxide.
The purpose of this study is to investigate the antioxidative effect of H2S in RPE cells and its role in autophagy.
The results show that exogenous H2S (NaHS) pretreatment effectively reduces H2O2-induced oxidative stress, oxidative damage, apoptosis, and inflammation in ARPE-19 cells.
NaHS pretreatment also decreased autophagy levels raised by H2O2, increased cell viability, and ameliorated cell morphological damage.
Interestingly, the suppression of autophagy by its inhibitor 3-MA showed an increase of cell viability, amelioration of morphology, and a decrease of apoptosis.
In summary, oxidative stress causes ARPE-19 cell injury by inducing cell autophagy.
However exogenous H2S is shown to attenuate ARPE-19 cell injury, decrease apoptosis, and reduce the occurrence of autophagy-mediated by oxidative stress.
These findings suggest that autophagy might play a crucial role in the development of AMD, and exogenous H2S has a potential value in the treatment of AMD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hu, Liming& Guo, Jia& Zhou, Li& Zhu, Sen& Wang, Chunming& Liu, Jiawei…[et al.]. 2020. Hydrogen Sulfide Protects Retinal Pigment Epithelial Cells from Oxidative Stress-Induced Apoptosis and Affects Autophagy. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1205823
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hu, Liming…[et al.]. Hydrogen Sulfide Protects Retinal Pigment Epithelial Cells from Oxidative Stress-Induced Apoptosis and Affects Autophagy. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-15.
https://search.emarefa.net/detail/BIM-1205823
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hu, Liming& Guo, Jia& Zhou, Li& Zhu, Sen& Wang, Chunming& Liu, Jiawei…[et al.]. Hydrogen Sulfide Protects Retinal Pigment Epithelial Cells from Oxidative Stress-Induced Apoptosis and Affects Autophagy. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1205823
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1205823
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر