Differences in the Hemolytic Behavior of Two Isomers in Ophiopogon japonicus In Vitro and In Vivo and Their Risk Warnings
المؤلفون المشاركون
Tang, Xiang-Lin
Gao, Yue
Xu, Huan-Hua
Jiang, Zhen-Hong
Sun, Yu-Ting
Qiu, Li-Zhen
Xu, Long-Long
Ma, Zeng-Chun
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-12-15
دولة النشر
مصر
عدد الصفحات
16
التخصصات الرئيسية
الملخص EN
Ophiopogonin D (OPD) and Ophiopogonin D′ (OPD′) are two bioactive ingredients in Ophiopogon japonicus.
Previously published studies have often focused on the therapeutic effects related to OPD’s antioxidant capacity but underestimated the cytotoxicity-related side effects of OPD′, which may result in unpredictable risks.
In this study, we reported another side effect of OPD′, hemolysis, and what was unexpected was that this side effect also appeared with OPD.
Although hemolysis effects for saponins are familiar to researchers, the hemolytic behavior of OPD or OPD′ and the interactions between these two isomers are unique.
Therefore, we investigated the effects of OPD and OPD′ alone or in combination on the hemolytic behavior in vitro and in vivo and adopted chemical compatibility and proteomics methods to explain the potential mechanism.
Meanwhile, to explain the drug-drug interactions (DDIs), molecular modeling was applied to explore the possible common targets.
In this study, we reported that OPD′ caused hemolysis both in vitro and in vivo, while OPD only caused hemolysis in vivo.
We clarified the differences and DDIs in the hemolytic behavior of the two isomers.
An analysis of the underlying mechanism governing this phenomenon showed that hemolysis caused by OPD or OPD′ was related to the destruction of the redox balance of erythrocytes.
In vivo, in addition to the redox imbalance, the proteomics data demonstrated that lipid metabolic disorders and mitochondrial energy metabolism are extensively involved by hemolysis.
We provided a comprehensive description of the hemolysis of two isomers in Ophiopogon japonicus, and risk warnings related to hemolysis were presented.
Our research also provided a positive reference for the development and further research of such bioactive components.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Xu, Huan-Hua& Jiang, Zhen-Hong& Sun, Yu-Ting& Qiu, Li-Zhen& Xu, Long-Long& Tang, Xiang-Lin…[et al.]. 2020. Differences in the Hemolytic Behavior of Two Isomers in Ophiopogon japonicus In Vitro and In Vivo and Their Risk Warnings. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-16.
https://search.emarefa.net/detail/BIM-1205827
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Xu, Huan-Hua…[et al.]. Differences in the Hemolytic Behavior of Two Isomers in Ophiopogon japonicus In Vitro and In Vivo and Their Risk Warnings. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-16.
https://search.emarefa.net/detail/BIM-1205827
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Xu, Huan-Hua& Jiang, Zhen-Hong& Sun, Yu-Ting& Qiu, Li-Zhen& Xu, Long-Long& Tang, Xiang-Lin…[et al.]. Differences in the Hemolytic Behavior of Two Isomers in Ophiopogon japonicus In Vitro and In Vivo and Their Risk Warnings. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-16.
https://search.emarefa.net/detail/BIM-1205827
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1205827
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر