Diazepam and Its Disinfection Byproduct Promote the Early Development of Nervous System in Zebrafish Embryos
المؤلفون المشاركون
Huang, Xiaoyong
Shi, Jiachen
Shao, Bing
Zhao, Xiaole
Zhu, Kui
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-11-30
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
The widely used diazepam, as central nervous system inhibitor, has found to be ubiquitous in surface water and drinking water.
Moreover, a series of byproducts such as 2-methylamino-5-chlorobenzophenone (MACB) were generated after the chlorine disinfection process.
However, little information is available about the neurobiological effects of these emerging chemicals at low doses, especially on infants and children.
Here, we exposed zebrafish (Danio rerio) embryos to diazepam and MACB at 0.05, 0.5, and 5 nM, which were equivalent to environmental levels.
Both diazepam and MACB increased the somite number and promoted nervous development of transgenic zebrafish [Tg (elavl3: EGFP) larvae] at 72 hours postfertilization ( hpf).
Both diazepam and MACB also disrupted the homeostasis of adenosine monophosphate, valine, methionine, and fumaric acid in zebrafish embryos at 12 hpf.
Additionally, the locomotor behavior activity of zebrafish was significantly enhanced after 120-hour sustained exposure to diazepam or MACB.
Moreover, the mRNA expression levels of oct4, sox2, and nanog, modulating the pluripotency and self-renewal, were upregulated by diazepam and MACB in zebrafish embryo.
Altogether, diazepam and MACB stimulate developmental neurogenesis and may induce neuronal excitotoxicity at quite low doses.
These results indicated that the chronic exposure to psychoactive drugs may pose a potential risk to the development of the nervous system in infancy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhao, Xiaole& Huang, Xiaoyong& Shi, Jiachen& Zhu, Kui& Shao, Bing. 2020. Diazepam and Its Disinfection Byproduct Promote the Early Development of Nervous System in Zebrafish Embryos. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1205850
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhao, Xiaole…[et al.]. Diazepam and Its Disinfection Byproduct Promote the Early Development of Nervous System in Zebrafish Embryos. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1205850
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhao, Xiaole& Huang, Xiaoyong& Shi, Jiachen& Zhu, Kui& Shao, Bing. Diazepam and Its Disinfection Byproduct Promote the Early Development of Nervous System in Zebrafish Embryos. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1205850
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1205850
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر