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Baicalin Represses CEBPβ via Its Antioxidative Effect in Parkinson’s Disease
المؤلفون المشاركون
Lei, Kecheng
Shen, Yijue
He, Yijing
Zhang, Liwen
Zhang, Jingxing
Tong, Weifang
Xu, Yichun
Jin, Lingjing
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-05-22
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Parkinson’s disease (PD) is a neurodegenerative disease characterized by the gradual loss of dopaminergic (DA) neurons in the substantia nigra (SN) and the formation of intracellular Lewy bodies (LB) in the brain, which aggregates α-synuclein (α-Syn) as the main component.
The interest of flavonoids as potential neuroprotective agents is increasing due to its high efficiency and low side effects.
Baicalin is one of the flavonoid compounds, which is a predominant flavonoid isolated from Scutellaria baicalensis Georgi.
However, the key molecular mechanism by which Baicalin can prevent the PD pathogenesis remains unclear.
In this study, we used bioinformatic assessment including Gene Ontology (GO) to elucidate the correlation between oxidative stress and PD pathogenesis.
RNA-Seq methods were used to examine the global expression profiles of noncoding RNAs and found that C/EBPβ expression was upregulated in PD patients compared with healthy controls.
Interestingly, Baicalin could protect DA neurons against reactive oxygen species (ROS) and decreased C/EBPβ and α-synuclein expression in pLVX-Tet3G-α-synuclein SH-SY5Y cells.
In a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induced PD mouse model, the results revealed that treatment with Baicalin improved the PD model’s behavioral performance and reduced dopaminergic neuron loss in the substantia nigra, associated with the inactivation of proinflammatory cytokines and oxidative stress.
Hence, our study supported that Baicalin repressed C/EBPβ via redox homeostasis, which may be an effective potential treatment for PD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lei, Kecheng& Shen, Yijue& He, Yijing& Zhang, Liwen& Zhang, Jingxing& Tong, Weifang…[et al.]. 2020. Baicalin Represses CEBPβ via Its Antioxidative Effect in Parkinson’s Disease. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1205913
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lei, Kecheng…[et al.]. Baicalin Represses CEBPβ via Its Antioxidative Effect in Parkinson’s Disease. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-14.
https://search.emarefa.net/detail/BIM-1205913
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lei, Kecheng& Shen, Yijue& He, Yijing& Zhang, Liwen& Zhang, Jingxing& Tong, Weifang…[et al.]. Baicalin Represses CEBPβ via Its Antioxidative Effect in Parkinson’s Disease. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1205913
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1205913
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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