![](/images/graphics-bg.png)
SIRT1 Modulators in Experimentally Induced Liver Injury
المؤلفون المشاركون
Farghali, Hassan
Kemelo, Mighty Kgalalelo
Canová, Nikolina Kutinová
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-06-02
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
This article is directed at highlighting the involvement of the endogenous stress sensor SIRT1 (silent information regulator T1) as a possible factor involved in hepatoprotection.
The selective SIRT1 modulators whether activators (STACs) or inhibitors are being tried experimentally and clinically.
We discuss the modulation of SIRT1 on cytoprotection or even cytotoxicity in the liver chemically injured by hepatotoxic agents in rats, to shed light on the crosstalk between SIRT1 and its modulators.
A combination of D-galactosamine and lipopolysaccharide (D-GalN/LPS) downregulated SIRT1 expression, while SIRT1 activators, SRT1720, resveratrol, and quercetin, upregulated SIRT1 and alleviated D-GalN/LPS-induced acute hepatotoxicity.
Liver injury markers exhibited an inverse relationship with SIRT1 expression.
However, under subchronic hepatotoxicity, quercetin decreased the significant increase in SIRT1 expression to lower levels which are still higher than normal ones and mitigated the liver-damaging effects of carbon tetrachloride.
Each of these STACs was hepatoprotective and returned the conventional antioxidant enzymes to the baseline.
Polyphenols tend to fine-tune SIRT1 expression towards normal in the liver of intoxicated rats in both acute and subchronic studies.
Together, all these events give an impression that the cytoprotective effects of SIRT1 are exhibited within a definite range of expression.
The catalytic activity of SIRT1 is important in the hepatoprotective effects of polyphenols where SIRT1 inhibitors block and the allosteric SIRT1 activators mimic the hepatoprotective effects of polyphenols.
Our findings indicate that the pharmacologic modulation of SIRT1 could represent both an important move in alleviating hepatic insults and a future major step in the treatment of xenobiotic-induced hepatotoxicity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Farghali, Hassan& Kemelo, Mighty Kgalalelo& Canová, Nikolina Kutinová. 2019. SIRT1 Modulators in Experimentally Induced Liver Injury. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1205920
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Farghali, Hassan…[et al.]. SIRT1 Modulators in Experimentally Induced Liver Injury. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-15.
https://search.emarefa.net/detail/BIM-1205920
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Farghali, Hassan& Kemelo, Mighty Kgalalelo& Canová, Nikolina Kutinová. SIRT1 Modulators in Experimentally Induced Liver Injury. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1205920
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1205920
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)