A Stereological Study of the Toxic Effects of Cerium Oxide during Pregnancy on Kidney Tissues in Neonatal NMRI Mice
المؤلفون المشاركون
Peluso, Ilaria
Nemati, Afsaneh
Assadollahi, Vahideh
Abbaszadeh, Abolfazl
Beigi-boroujeni, Mandana
Khanipur, Zahra
Gholami, Mohammadreza
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-06-23
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Background.
Both antioxidant and prooxidant activities have been previously reported for cerium oxide (CeO2).
The aim of this study was to investigate the effects of CeO2 at different doses on changes in kidney tissues and markers in neonatal mice.
Methods.
We randomly divided 30 pregnant NMRI mice into five groups (n=6 per group)—a control group and four groups treated with intraperitoneal (i.p.) administration of different doses of CeO2 (10, 25, 80, or 250 mg/kg body weight (bw)) on gestation days (GD) 7 and GD14.
At the end of the treatment period, we analyzed the kidney tissues and serum samples.
The levels of two serum redox markers, malondialdehyde (MDA) and ferric reducing/antioxidant power (FRAP), were determined.
Data were analyzed using one-way ANOVA and Tukey’s test, and a P value of <0.05 was considered significant.
Results.
The mean total volumes of the renal corpuscle, glomeruli, and Bowman’s capsule membranes significantly increased, and there was a significant decrease in the mean total volume of Bowman’s space in the high-dose CeO2 group compared to that in the control group.
No statistically significant differences existed in the serum levels of MDA and FRAP in the treated and control groups.
Conclusion.
Our results suggest that high doses of CeO2 impair fetal renal development in pregnant mice, which results in kidney damage.
Therefore, CeO2 administration during pregnancy could have dose-dependent adverse effects on the developing kidneys in neonates.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Nemati, Afsaneh& Assadollahi, Vahideh& Peluso, Ilaria& Abbaszadeh, Abolfazl& Beigi-boroujeni, Mandana& Khanipur, Zahra…[et al.]. 2020. A Stereological Study of the Toxic Effects of Cerium Oxide during Pregnancy on Kidney Tissues in Neonatal NMRI Mice. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1205965
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Nemati, Afsaneh…[et al.]. A Stereological Study of the Toxic Effects of Cerium Oxide during Pregnancy on Kidney Tissues in Neonatal NMRI Mice. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1205965
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Nemati, Afsaneh& Assadollahi, Vahideh& Peluso, Ilaria& Abbaszadeh, Abolfazl& Beigi-boroujeni, Mandana& Khanipur, Zahra…[et al.]. A Stereological Study of the Toxic Effects of Cerium Oxide during Pregnancy on Kidney Tissues in Neonatal NMRI Mice. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1205965
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1205965
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر