Lycorine Attenuates Autophagy in Osteoclasts via an Axis of mROSTRPML1TFEB to Reduce LPS-Induced Bone Loss
المؤلفون المشاركون
Park, Hyun-Jung
Gholam-Zadeh, Malihatosadat
Suh, Jae-Hee
Choi, Hye-Sun
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-10-08
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Lycorine, a plant alkaloid, exhibits anti-inflammatory activity by acting in macrophages that share precursor cells with osteoclasts (OCs).
We hypothesized that lycorine might decrease bone loss by acting in OCs after lipopolysaccharide (LPS) stimulation, since OCs play a main role in LPS-induced bone loss.
Microcomputerized tomography (μCT) analysis revealed that lycorine attenuated LPS-induced bone loss in mice.
In vivo tartrate-resistant acid phosphatase (TRAP) staining showed that increased surface area and number of OCs in LPS-treated mice were also decreased by lycorine treatment, suggesting that OCs are responsible for the bone-sparing effect of lycorine.
In vitro, the increased number and activity of OCs induced by LPS were reduced by lycorine.
Lycorine also decreased LPS-induced autophagy in OCs by evaluation of decreased lipidated form of microtubule-associated proteins 1A/1B light chain 3B (LC3) (LC3II) and increased sequestosome 1 (p62).
Lycorine attenuated oxidized transient receptor potential cation channel, mucolipin subfamily (TRPML1) by reducing mitochondrial reactive oxygen species (mROS) and decreased transcription factor EB (TFEB) nuclear translocation.
Lycorine reduced the number and activity of OCs by decreasing autophagy in OCs via an axis of mROS/TRPML1/TFEB.
Collectively, lycorine protected against LPS-induced bone loss by acting in OCs.
Our data highlight the therapeutic potential of lycorine for protection against inflammatory bone loss.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Park, Hyun-Jung& Gholam-Zadeh, Malihatosadat& Suh, Jae-Hee& Choi, Hye-Sun. 2019. Lycorine Attenuates Autophagy in Osteoclasts via an Axis of mROSTRPML1TFEB to Reduce LPS-Induced Bone Loss. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1206017
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Park, Hyun-Jung…[et al.]. Lycorine Attenuates Autophagy in Osteoclasts via an Axis of mROSTRPML1TFEB to Reduce LPS-Induced Bone Loss. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1206017
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Park, Hyun-Jung& Gholam-Zadeh, Malihatosadat& Suh, Jae-Hee& Choi, Hye-Sun. Lycorine Attenuates Autophagy in Osteoclasts via an Axis of mROSTRPML1TFEB to Reduce LPS-Induced Bone Loss. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1206017
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1206017
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر