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Apigenin Protects Mouse Retina against Oxidative Damage by Regulating the Nrf2 Pathway and Autophagy
المؤلفون المشاركون
Li, Min
Yang, Yan
Zhang, Yuanzhong
Yu, Hai-tao
Xu, Xin-rong
Hang, Li
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-05-14
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Oxidative stress is a critical factor in the pathology of age-related macular degeneration (AMD).
Apigenin (AP) is a flavonoid with an outstanding antioxidant activity.
We had previously observed that AP protected APRE-19 cells against oxidative injury in vitro.
However, AP has poor water and fat solubility, which determines its low oral bioavailability.
In this study, we prepared the solid dispersion of apigenin (AP-SD).
The solubility and dissolution of AP-SD was significantly better than that of the original drug, so the oral bioavailability in rats was better than that of the original drug.
Then, the effects of AP-SD on the retina of a model mouse with dry AMD were assessed by fundus autofluorescence (FAF), optical coherence tomography (OCT), and electron microscopy; the results revealed that AP-SD alleviated retinopathy.
Further research found that AP-SD promoted the nuclear translocation of Nrf2 and increased expression levels of the Nrf2 and target genes HO-1 and NQO-1.
AP-SD enhanced the activities of SOD and GSH-Px and decreased the levels of ROS and MDA.
Furthermore, AP-SD upregulated the expressions of p62 and LC3II in an Nrf2-dependent manner.
However, these effects of AP-SD were observed only in the retina of Nrf2 WT mice, not in Nrf2 KO mice.
In addition, the therapeutic effect of AP-SD was dose dependent, and AP did not work.
In conclusion, AP-SD significantly enhanced the bioavailability of the original drug and reduced retinal oxidative injury in the model mouse of dry AMD in vivo.
The results of the underlying mechanism showed that AP-SD upregulated the expression of antioxidant enzymes through the Nrf2 pathway and upregulated autophagy, thus inhibiting retinal oxidative damage.
AP-SD may be a potential compound for the treatment of dry AMD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Yuanzhong& Yang, Yan& Yu, Hai-tao& Li, Min& Hang, Li& Xu, Xin-rong. 2020. Apigenin Protects Mouse Retina against Oxidative Damage by Regulating the Nrf2 Pathway and Autophagy. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1206049
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Yuanzhong…[et al.]. Apigenin Protects Mouse Retina against Oxidative Damage by Regulating the Nrf2 Pathway and Autophagy. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-14.
https://search.emarefa.net/detail/BIM-1206049
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Yuanzhong& Yang, Yan& Yu, Hai-tao& Li, Min& Hang, Li& Xu, Xin-rong. Apigenin Protects Mouse Retina against Oxidative Damage by Regulating the Nrf2 Pathway and Autophagy. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1206049
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1206049
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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