Worsening of Oxidative Stress, DNA Damage, and Atherosclerotic Lesions in Aged LDLr-- Mice after Consumption of Guarana Soft Drinks
المؤلفون المشاركون
Vasquez, Elisardo Corral
Nogueira, Breno Valentim
Andrade, Tadeu Uggere
Campos-Toimil, Manuel
Pereira, Thiago M. C.
Chisté, Layla Aparecida
Pereira, Beatriz Peters
Porto, Marcella Leite
de Oliveira, Jairo Pinto
de Assis, Arícia Leone Evangelista Monteiro
Meyrelles, Silvana S.
Campagnaro, Bianca P.
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-06-10
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Background.
Excessive consumption of soft drinks (SD) has become a health problem worldwide due to its association with related cardiovascular diseases.
We investigated the possible impacts associated with the consumption of Brazilian guarana (normal and zero) SD in dyslipidemic mice, thus mitigating potential clinical confounders such as poor-quality diet, lifestyle, body composition, and/or comorbidities.
Methods.
Sixteen-month-old LDLr-/- mice were divided into the following groups: (1) control; (2) GSD: normal guarana SD; and (3) Z-GSD: zero guarana SD.
All were fed ad libitum, and blood pressure was measured noninvasively.
After 8 weeks, aorta, blood, liver, and stomach samples were collected for histological and biochemical analyses.
Results.
Guarana soft drinks increased atherosclerosis (~60%) and were associated with hypercholesterolemia, hypertension, oxidative stress, DNA fragmentation, and apoptosis (~2-fold) of blood cells, besides presenting an increase in liver and gastric damage even in normoglycemia.
Interestingly, Z-GSD did not cause the aforementioned changes, except in hemodynamic and renal parameters.
Conclusions.
Chronic administration of GSD is prooxidative, compromising the cardiovascular, gastric, and hepatic systems; the effects are due at least in part to free sugar consumption but not to guarana extract per se.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chisté, Layla Aparecida& Pereira, Beatriz Peters& Porto, Marcella Leite& de Oliveira, Jairo Pinto& de Assis, Arícia Leone Evangelista Monteiro& Nogueira, Breno Valentim…[et al.]. 2019. Worsening of Oxidative Stress, DNA Damage, and Atherosclerotic Lesions in Aged LDLr-- Mice after Consumption of Guarana Soft Drinks. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1206054
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chisté, Layla Aparecida…[et al.]. Worsening of Oxidative Stress, DNA Damage, and Atherosclerotic Lesions in Aged LDLr-- Mice after Consumption of Guarana Soft Drinks. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-13.
https://search.emarefa.net/detail/BIM-1206054
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chisté, Layla Aparecida& Pereira, Beatriz Peters& Porto, Marcella Leite& de Oliveira, Jairo Pinto& de Assis, Arícia Leone Evangelista Monteiro& Nogueira, Breno Valentim…[et al.]. Worsening of Oxidative Stress, DNA Damage, and Atherosclerotic Lesions in Aged LDLr-- Mice after Consumption of Guarana Soft Drinks. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1206054
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1206054
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر