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The Combined Extract of Black Sticky Rice and Dill Improves Poststroke Cognitive Impairment in Metabolic Syndrome Condition
المؤلفون المشاركون
Wattanathorn, Jintanaporn
Wannanon, Panakaporn
Ohnon, Warin
Tong-Un, Terdthai
Muchimapura, Supaporn
Thukham-mee, Wipawee
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-19، 19ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-02-26
دولة النشر
مصر
عدد الصفحات
19
التخصصات الرئيسية
الملخص EN
Despite the increase in cognitive deficit following stroke in metabolic syndrome (MetS) condition, the therapeutic strategy is still limited.
Since oxidative stress and neuroinflammation play the crucial roles on the pathophysiology of aforementioned conditions, the cognitive enhancing effect of the combined extract of Oryza sativa and Anethum graveolens was considered based on their antioxidant, anti-inflammation, and neuroprotective effects together with the synergistic effect concept.
Male Wistar rats weighing 180-220 g were induced metabolic syndrome-like condition by using a high-carbohydrate high-fat diet (HCHF diet).
Then, reperfusion injury following cerebral ischemia was induced by the occlusion of right middle cerebral artery and treated with the combined extract of O.
sativa and A.
graveolens (OA extract) at doses of 0.5, 5, and 50 mg/kg BW once daily for 21 days.
Spatial memory was assessed every 7 days throughout the experimental period.
At the end of the study, neuron and glial fibrillary acidic protein- (GFAP-) positive cell densities, the oxidative stress status, AChE, and the expression of proinflammatory cytokines (TNF-α, IL-6) in the hippocampus were determined.
The results showed that OA extract at all doses used in this study significantly improved memory together with the reductions of MDA, TNF-α, IL-6, AChE, and density of GFAP-positive cell but increased neuron density in the hippocampus.
Taken together, OA is the potential cognitive enhancer in memory impairment following stroke in MetS condition.
The possible underlying mechanism may occur partly via the reductions of oxidative stress status, GFAP-positive cell density, and neuroinflammatory cytokines such as TNF-α and IL-6 together with the suppression of AChE activity in the hippocampus.
This study suggests that OA is the potential functional ingredient to improve the cognitive enhancer.
However, further clinical research is required.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ohnon, Warin& Wattanathorn, Jintanaporn& Thukham-mee, Wipawee& Muchimapura, Supaporn& Wannanon, Panakaporn& Tong-Un, Terdthai. 2019. The Combined Extract of Black Sticky Rice and Dill Improves Poststroke Cognitive Impairment in Metabolic Syndrome Condition. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-19.
https://search.emarefa.net/detail/BIM-1206093
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ohnon, Warin…[et al.]. The Combined Extract of Black Sticky Rice and Dill Improves Poststroke Cognitive Impairment in Metabolic Syndrome Condition. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-19.
https://search.emarefa.net/detail/BIM-1206093
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ohnon, Warin& Wattanathorn, Jintanaporn& Thukham-mee, Wipawee& Muchimapura, Supaporn& Wannanon, Panakaporn& Tong-Un, Terdthai. The Combined Extract of Black Sticky Rice and Dill Improves Poststroke Cognitive Impairment in Metabolic Syndrome Condition. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-19.
https://search.emarefa.net/detail/BIM-1206093
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1206093
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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