![](/images/graphics-bg.png)
Diquat Determines a Deregulation of lncRNA and mRNA Expression in the Liver of Postweaned Piglets
المؤلفون المشاركون
Yang, Dandan
Chen, Wei
Zeng, Yongqing
Wang, Jin
Li, Zhi-xin
Liu, Pei-qi
Wang, Zhi-qiang
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-05-12
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Oxidative stress is detrimental to animals and can depress the growth performance and regulate the gene expression of animals.
However, it remains unclear how oxidative stress regulates the expression of long noncoding RNAs (lncRNAs) and mRNAs.
Therefore, the purpose of this article was to explore the profiles of lncRNAs and mRNAs in the liver of piglets under oxidative stress.
Here, we constructed a piglet oxidative stress model induced by diquat and evaluated the effects of oxidative stress on the growth performance and antioxidant enzyme activity of piglets.
We also used RNA-Seq to examine the global expression of lncRNAs and mRNAs in piglets under oxidative stress.
The targets of lncRNAs and mRNAs were enriched in gene ontology (GO) terms and signaling pathways.
The results show that the growth performance and activities of antioxidant enzymes were decreased in piglets under oxidative stress.
Moreover, eight lncRNAs (6 upregulated and 2 downregulated) and 30 mRNAs (8 upregulated and 22 downregulated) were differentially expressed in the oxidative stress group of piglets compared to the negative control group.
According to biological processes in enriched GO terms, the oxoacid metabolic process, intramolecular oxidoreductase activity, and oxidation-reduction process play important roles in oxidative stress.
Pathway analysis showed that the signaling pathways involved in insulin and glucose metabolism had a close relationship with oxidative stress.
Further in vitro experiments showed that the expression of the upregulated gene GNMT was significantly increased in primary porcine hepatocytes after diquat stimulation.
In contrast, the level of the downregulated gene GCK was significantly decreased at 12 h in primary porcine hepatocytes after diquat stimulation.
Our results expand our knowledge of the lncRNAs and mRNAs transcribed in the livers of piglets under oxidative stress and provide a basis for future research on the molecular mechanisms mediating oxidative stress and tissue damage.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Jin& Li, Zhi-xin& Yang, Dandan& Liu, Pei-qi& Wang, Zhi-qiang& Zeng, Yongqing…[et al.]. 2019. Diquat Determines a Deregulation of lncRNA and mRNA Expression in the Liver of Postweaned Piglets. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1206131
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Jin…[et al.]. Diquat Determines a Deregulation of lncRNA and mRNA Expression in the Liver of Postweaned Piglets. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1206131
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Jin& Li, Zhi-xin& Yang, Dandan& Liu, Pei-qi& Wang, Zhi-qiang& Zeng, Yongqing…[et al.]. Diquat Determines a Deregulation of lncRNA and mRNA Expression in the Liver of Postweaned Piglets. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1206131
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1206131
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)