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A Proteomic Network Approach across the Kidney Stone Disease Reveals Endoplasmic Reticulum Stress and Crystal-Cell Interaction in the Kidney
المؤلفون المشاركون
Taguchi, Kazumi
Li, Yang
Yang, Baoyu
Gao, Bing
Lu, Xiuli
Li, Yuanyuan
Yu, Daojun
Zhang, Weiwen
Duan, Chaojie
Kohri, Kenjiro
Yasui, Takahiro
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-10-27
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Crystal-cell interactions are a vital step toward kidney stone formation.
However, its mechanisms remained unclear.
Here, a protein-protein interaction (PPI) network analysis of a kidney stone revealed that the proteins were enriched in a posttranslational protein modification process in the endoplasmic reticulum (ER).
The in vitro study showed that the markers of ER stress, including Bip and CHOP, were upregulated, PERK and ATF6 were activated, and XBP-1 mRNA was spliced.
An ER stress-specific protein, caspase-12, was activated in the apoptotic cells induced by calcium oxalate monohydrate (COM) crystals.
The treatment with tunicamycin, an ER stress inducer, promoted the crystal-cell adhesion assayed by atomic absorption, reduced cell viability assayed by MTT, and downregulated the expression of proteins involved in the crystal formations.
The treatment with salubrinal, an ER stress inhibitor, reversed the above effects for both tunicamycin and COM crystals.
The aforementioned main observations were supported by in vivo study.
These data demonstrated that ER stress was an essentially biological process of crystal-cell interactions.
Our findings suggest that blocking ER stress may become a potential approach to preventing a kidney stone.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yang, Baoyu& Lu, Xiuli& Li, Yang& Li, Yuanyuan& Yu, Daojun& Zhang, Weiwen…[et al.]. 2019. A Proteomic Network Approach across the Kidney Stone Disease Reveals Endoplasmic Reticulum Stress and Crystal-Cell Interaction in the Kidney. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1206335
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yang, Baoyu…[et al.]. A Proteomic Network Approach across the Kidney Stone Disease Reveals Endoplasmic Reticulum Stress and Crystal-Cell Interaction in the Kidney. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-13.
https://search.emarefa.net/detail/BIM-1206335
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yang, Baoyu& Lu, Xiuli& Li, Yang& Li, Yuanyuan& Yu, Daojun& Zhang, Weiwen…[et al.]. A Proteomic Network Approach across the Kidney Stone Disease Reveals Endoplasmic Reticulum Stress and Crystal-Cell Interaction in the Kidney. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1206335
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1206335
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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