Association of Angiotensin I Converting Enzyme Insertion287 bp Deletion Polymorphisms and Proliferative Prostatic Diseases among Lebanese Men
المؤلفون المشاركون
El Ezzi, Asmahan A.
Clawson, Jordan M.
El-Saidi, Mohammed A.
Zaidan, Wissam R.
Kovash, Abigail
Orellana, Jeremy
Thornock, AnnaKarina
Kuddus, Ruhul H.
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-02-07
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Background.
Angiotensin I converting enzyme (ACE) insertion (I) and 287 bp Alu repeat DNA fragment deletion (D) polymorphisms have been indicated in various cancers.
Here, we investigated I/D polymorphisms in prostate cancer (PCa) and benign prostate hyperplasia (BPH) among Lebanese men.
Methods.
Blood DNA extracted from 69 control subjects, 69 subjects with clinically confirmed PCa, and 69 subjects with clinical BPH, all the subjects were aged 50 years or older, was subjected to the polymerase chain reaction.
The PCR products were resolved in polyacrylamide gels to determine II, ID, and DD genotypes.
The odds ratios (OR), 95% confidence intervals (CI), and p values of the allele frequencies and genotype ratios were calculated for establishing possible association of the alleles and/or genotypes and PCa and/or BPH.
Results.
The proportions of II, ID, and DD genotypes were significantly different from Hardy–Weinberg equilibrium for BPH and PCa groups (but not the control group), mostly due to overabundance of the ID genotypes.
There was no significant difference in the I and D allele frequencies between the control groups and the affected groups.
The ratio of (DD + ID)/II is significantly lower among the control group compared to the BPH group (RR = 8.92, p=0.042), and the ratio of ID/(DD + II) is significantly lower among the control group compared to the affected groups (RR = 1.99, p=0.021).
Conclusions.
Our data indicate that the D allele of the I/D polymorphisms of the ACE gene is associated with increased risk of BPH, and the ID genotype is a risk factor for both BPH and PCa among Lebanese males.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
El Ezzi, Asmahan A.& Clawson, Jordan M.& El-Saidi, Mohammed A.& Zaidan, Wissam R.& Kovash, Abigail& Orellana, Jeremy…[et al.]. 2020. Association of Angiotensin I Converting Enzyme Insertion287 bp Deletion Polymorphisms and Proliferative Prostatic Diseases among Lebanese Men. Prostate Cancer،Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1206346
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
El Ezzi, Asmahan A.…[et al.]. Association of Angiotensin I Converting Enzyme Insertion287 bp Deletion Polymorphisms and Proliferative Prostatic Diseases among Lebanese Men. Prostate Cancer No. 2020 (2020), pp.1-6.
https://search.emarefa.net/detail/BIM-1206346
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
El Ezzi, Asmahan A.& Clawson, Jordan M.& El-Saidi, Mohammed A.& Zaidan, Wissam R.& Kovash, Abigail& Orellana, Jeremy…[et al.]. Association of Angiotensin I Converting Enzyme Insertion287 bp Deletion Polymorphisms and Proliferative Prostatic Diseases among Lebanese Men. Prostate Cancer. 2020. Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1206346
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1206346
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر