Ethanol Extract of Centipeda minima Exerts Antioxidant and Neuroprotective Effects via Activation of the Nrf2 Signaling Pathway
المؤلفون المشاركون
Wang, Qi
Liu, Yongqiang
Wang, Yi-Jie
Wang, Xin-Yue
Hao, Xu-Yi
Yan, Yong-Ming
Hong, Ming
Wei, Su-Fen
Zhou, Yi-Le
Cheng, Yong-Xian
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-04-03
دولة النشر
مصر
عدد الصفحات
16
التخصصات الرئيسية
الملخص EN
Oxidative stress is implicated in the pathogenesis of neurodegeneration and other aging-related diseases.
Previous studies have found that the whole herb of Centipeda minima has remarkable antioxidant activities.
However, there have been no reports on the neuroprotective effects of C.
minima, and the underlying mechanism of its antioxidant properties is unclear.
Here, we examined the underlying mechanism of the antioxidant activities of the ethanol extract of C.
minima (ECM) both in vivo and in vitro and found that ECM treatment attenuated glutamate and tert-butyl hydroperoxide (tBHP)-induced neuronal death, reactive oxygen species (ROS) production, and mitochondria dysfunction.
tBHP-induced phosphorylation of p38 mitogen-activated protein kinase (p38 MAPK) and c-Jun N-terminal kinases (JNK) was reduced by ECM, and ECM sustained phosphorylation level of extracellular signal regulated kinase (ERK) in SH-SY5Y and PC12 cells.
Moreover, ECM induced the activation of nuclear factor erythroid 2-related factor 2 (Nrf2) and the upregulation of phase II detoxification enzymes, including heme oxygenase-1 (HO-1), superoxide dismutase-2 (SOD2), and NAD(P)H quinone oxidoreductase-1 (NQO-1) in both two cell types.
In a D-galactose (D-gal) and aluminum muriate (AlCl3)-induced neurodegenerative mouse model, administration of ECM improved the learning and memory of mice in the Morris water maze test and ameliorated the effects of neurodegenerative disorders.
ECM sustained the expression level of postsynaptic density 95 (PSD95) and synaptophysin (SYN), activated the Nrf2 signaling pathway, and restored the levels of cellular antioxidants in the hippocampus of mice.
In addition, four sesquiterpenoids were isolated from C.
minima to identify the bioactive components responsible for the antioxidant activity of C.
minima; 6-O-angeloylplenolin and arnicolide D were found to be the active compounds responsible for the activation of the Nrf2 signaling pathway and inhibition of ROS production.
Our study examined the mechanism of C.
minima and its active components in the amelioration of oxidative stress, which holds the promise for the treatment of neurodegenerative disease.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Yi-Jie& Wang, Xin-Yue& Hao, Xu-Yi& Yan, Yong-Ming& Hong, Ming& Wei, Su-Fen…[et al.]. 2019. Ethanol Extract of Centipeda minima Exerts Antioxidant and Neuroprotective Effects via Activation of the Nrf2 Signaling Pathway. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-16.
https://search.emarefa.net/detail/BIM-1206381
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Yi-Jie…[et al.]. Ethanol Extract of Centipeda minima Exerts Antioxidant and Neuroprotective Effects via Activation of the Nrf2 Signaling Pathway. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-16.
https://search.emarefa.net/detail/BIM-1206381
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Yi-Jie& Wang, Xin-Yue& Hao, Xu-Yi& Yan, Yong-Ming& Hong, Ming& Wei, Su-Fen…[et al.]. Ethanol Extract of Centipeda minima Exerts Antioxidant and Neuroprotective Effects via Activation of the Nrf2 Signaling Pathway. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-16.
https://search.emarefa.net/detail/BIM-1206381
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1206381
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر